Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) ELISA Kits

The protein encoded by ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). Zusätzlich bieten wir Ihnen ASPSCR1 Antikörper (116) und ASPSCR1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Ratte ASPSCR1 ASPSCR1 691026  
Anti-Human ASPSCR1 ASPSCR1 79058 Q9BZE9
Anti-Maus ASPSCR1 ASPSCR1 68938 Q8VBT9
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Weitere ELISA Kits für ASPSCR1 Interaktionspartner

Human Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Interaktionspartner

  1. These results show that ASPL-TFE3 (zeige TFE3 ELISA Kits) regulates cell cycle progression and induces cellular senescence by up-regulating p21 (zeige CDKN1A ELISA Kits) expression.

  2. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der (zeige GDF3 ELISA Kits)(17)t(X:17)(p11 (zeige S100A10 ELISA Kits):q25), resulting in the fusion of the TFE3 (zeige TFE3 ELISA Kits) transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.

  3. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 (zeige TFE3 ELISA Kits) from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  4. ASPL is a cofactor of the hexameric ATPase (zeige DNAH8 ELISA Kits) complex, known as p97 (zeige EIF4G2 ELISA Kits). The central area in ASPL, containing both a SHP (zeige LAMC1 ELISA Kits) box and a UBX domain, is required for binding to the p97 (zeige EIF4G2 ELISA Kits) N-domain.

  5. Results support a gain-of-function role for ASPSCR1-TFE3 (zeige TFE3 ELISA Kits) contributing to proliferation and survival of cancer cells.

  6. Promotes methylation of VCP by METTL21D

  7. Data support a model in which TUG controls p97 (zeige EIF4G2 ELISA Kits) oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types.

  8. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 (zeige TFE3 ELISA Kits) fusion transcript would be the highly effective diagnostic technique.

  9. Immuno-detection of TFE3 (zeige TFE3 ELISA Kits) and RT-PCR-based identification of ASPL/TFE3 (zeige TFE3 ELISA Kits) fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma.

  10. Immunohistochemical discrimination between the ASPL-TFE3 (zeige TFE3 ELISA Kits) fusion proteins of alveolar soft part sarcoma

Mouse (Murine) Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Interaktionspartner

  1. Insulin (zeige INS ELISA Kits) acts through TUG proteins to control IRAP (zeige IL1RN ELISA Kits) targeting, similar to GLUT4 (zeige SLC2A4 ELISA Kits); the activity of vasopressin (zeige AVP ELISA Kits), an IRAP (zeige IL1RN ELISA Kits) substrate, is reduced in mice with disrupted TUG action in muscle.

  2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 (zeige TFE3 ELISA Kits) from human alveolar soft part sarcoma (ASPS (zeige DARS ELISA Kits)) generated a model that recapitulates the human tumor histologically and by expression profile.

  3. Data indicate that insulin (zeige INS ELISA Kits) stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4 (zeige SLC2A4 ELISA Kits))) to translocate GLUT4 (zeige SLC2A4 ELISA Kits) in muscle.

  4. Data suggest a model whereby insulin (zeige INS ELISA Kits) stimulates TUG cleavage to liberate GLUT4 (zeige SLC2A4 ELISA Kits) storage vesicles from the Golgi matrix, which promotes GLUT4 (zeige SLC2A4 ELISA Kits) translocation to the cell surface and enhances glucose uptake.

  5. TUG traps endocytosed GLUT4 (zeige SLC2A4 ELISA Kits) and tethers it intracellularly, and insulin (zeige INS ELISA Kits) mobilizes this pool of retained GLUT4 (zeige SLC2A4 ELISA Kits) by releasing this tether

  6. insulin (zeige INS ELISA Kits)-stimulated dissociation of TUG and GLUT4 (zeige SLC2A4 ELISA Kits) as an important action by which insulin (zeige INS ELISA Kits) stimulates glucose uptake.

ASPSCR1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X\;17)(p11\;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Genbezeichner und Symbole assoziert mit ASPSCR1

  • ASPSCR1, UBX domain containing tether for SLC2A4 (ASPSCR1) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 S homeolog (aspscr1.S) Antikörper
  • ASPSCR1, UBX domain containing tether for SLC2A4 (Aspscr1) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 (aspscr1) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 (Bm1_55980) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1) Antikörper
  • 1190006K01Rik Antikörper
  • ASPC Antikörper
  • ASPCR1 Antikörper
  • ASPL Antikörper
  • ASPS Antikörper
  • RCC17 Antikörper
  • TUG Antikörper
  • UBXD9 Antikörper
  • UBXN9 Antikörper

Bezeichner auf Proteinebene für ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1 , hypothetical protein LOC495145 , tether containing UBX domain for GLUT4 , UBX domain protein 9 , UBX domain-containing protein 9 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein , alveolar soft part sarcoma locus , renal cell carcinoma gene on chromosome 17 , renal cell carcinoma, papillary, 17 , renal papillary cell carcinoma protein 17 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog , tether, containing a UBX domain, for GLUT4

GENE ID SPEZIES
417384 Gallus gallus
495145 Xenopus laevis
691026 Rattus norvegicus
733865 Xenopus (Silurana) tropicalis
6106077 Brugia malayi
515670 Bos taurus
79058 Homo sapiens
68938 Mus musculus
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