anti-Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Antikörper

The protein encoded by ASPSCR1 contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). Zusätzlich bieten wir Ihnen ASPSCR1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ASPSCR1 691026  
ASPSCR1 79058 Q9BZE9
ASPSCR1 68938 Q8VBT9
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Showing 10 out of 116 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of ASPSCR1 Antibody (C-term) (ABIN652768) in Hela cell line lysates (35 µg/lane). ASPSCR1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with ASPSCR1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of ASPSCR1/TUG Antibody (C-term) in Hela cell line lysates (35ug/lane). ASPSCR1 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
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Human Kaninchen Unkonjugiert EIA, WB ASPSCR1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35µg/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow). Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene. 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
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Human Maus Unkonjugiert WB ASPSCR1 monoclonal antibody (M01), clone 3D10-1D11 Western Blot analysis of ASPSCR1 expression in Hela NE on formalin-fixed paraffin-embedded human breast cancer (antibody concentration 3 µg/mL). 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
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Human Kaninchen Unkonjugiert WB WB Suggested Anti-ASPSCR1 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Fetal Lung 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Maus Maus Unkonjugiert ELISA, WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
399,32 €
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 6 bis 8 Tage
318,48 €
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Maus Maus Unkonjugiert ELISA, WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
374,52 €
Details
Human Kaninchen Unkonjugiert WB ASPSCR1 Antibody (N-term)  western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow). Western blot analysis of ASPSCR1 (arrow) using rabbit polyclonal ASPSCR1 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ASPSCR1 gene. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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ASPSCR1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-ASPSCR1 Antikörper

  1. Mouse (Murine) Monoclonal ASPSCR1 Primary Antibody für ELISA, WB - ABIN1724649 : Bogan, Hendon, McKee, Tsao, Lodish: Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. in Nature 2003 (PubMed)

Weitere Antikörper gegen ASPSCR1 Interaktionspartner

Human Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Interaktionspartner

  1. These results show that ASPL-TFE3 (zeige TFE3 Antikörper) regulates cell cycle progression and induces cellular senescence by up-regulating p21 (zeige CDKN1A Antikörper) expression.

  2. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der (zeige GDF3 Antikörper)(17)t(X:17)(p11 (zeige S100A10 Antikörper):q25), resulting in the fusion of the TFE3 (zeige TFE3 Antikörper) transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.

  3. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 (zeige TFE3 Antikörper) from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile.

  4. ASPL is a cofactor of the hexameric ATPase (zeige DNAH8 Antikörper) complex, known as p97 (zeige EIF4G2 Antikörper). The central area in ASPL, containing both a SHP (zeige LAMC1 Antikörper) box and a UBX domain, is required for binding to the p97 (zeige EIF4G2 Antikörper) N-domain.

  5. Results support a gain-of-function role for ASPSCR1-TFE3 (zeige TFE3 Antikörper) contributing to proliferation and survival of cancer cells.

  6. Promotes methylation of VCP by METTL21D

  7. Data support a model in which TUG controls p97 (zeige EIF4G2 Antikörper) oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types.

  8. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 (zeige TFE3 Antikörper) fusion transcript would be the highly effective diagnostic technique.

  9. Immuno-detection of TFE3 (zeige TFE3 Antikörper) and RT-PCR-based identification of ASPL/TFE3 (zeige TFE3 Antikörper) fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma.

  10. Immunohistochemical discrimination between the ASPL-TFE3 (zeige TFE3 Antikörper) fusion proteins of alveolar soft part sarcoma

Mouse (Murine) Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1) Interaktionspartner

  1. Insulin (zeige INS Antikörper) acts through TUG proteins to control IRAP (zeige IL1RN Antikörper) targeting, similar to GLUT4 (zeige SLC2A4 Antikörper); the activity of vasopressin (zeige AVP Antikörper), an IRAP (zeige IL1RN Antikörper) substrate, is reduced in mice with disrupted TUG action in muscle.

  2. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 (zeige TFE3 Antikörper) from human alveolar soft part sarcoma (ASPS (zeige DARS Antikörper)) generated a model that recapitulates the human tumor histologically and by expression profile.

  3. Data indicate that insulin (zeige INS Antikörper) stimulates proteolysis of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4 (zeige SLC2A4 Antikörper))) to translocate GLUT4 (zeige SLC2A4 Antikörper) in muscle.

  4. Data suggest a model whereby insulin (zeige INS Antikörper) stimulates TUG cleavage to liberate GLUT4 (zeige SLC2A4 Antikörper) storage vesicles from the Golgi matrix, which promotes GLUT4 (zeige SLC2A4 Antikörper) translocation to the cell surface and enhances glucose uptake.

  5. TUG traps endocytosed GLUT4 (zeige SLC2A4 Antikörper) and tethers it intracellularly, and insulin (zeige INS Antikörper) mobilizes this pool of retained GLUT4 (zeige SLC2A4 Antikörper) by releasing this tether

  6. insulin (zeige INS Antikörper)-stimulated dissociation of TUG and GLUT4 (zeige SLC2A4 Antikörper) as an important action by which insulin (zeige INS Antikörper) stimulates glucose uptake.

ASPSCR1 Antigen-Profil

Protein Überblick

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X\;17)(p11\;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.

Genbezeichner und Symbole assoziert mit ASPSCR1

  • alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 (aspscr1) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1) Antikörper
  • alveolar soft part sarcoma chromosome region, candidate 1 (Bm1_55980) Antikörper
  • 1190006K01Rik Antikörper
  • ASPC Antikörper
  • ASPCR1 Antikörper
  • ASPL Antikörper
  • ASPS Antikörper
  • RCC17 Antikörper
  • TUG Antikörper
  • UBXD9 Antikörper
  • UBXN9 Antikörper

Bezeichner auf Proteinebene für ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1 , hypothetical protein LOC495145 , tether containing UBX domain for GLUT4 , UBX domain protein 9 , UBX domain-containing protein 9 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein , alveolar soft part sarcoma locus , renal cell carcinoma gene on chromosome 17 , renal cell carcinoma, papillary, 17 , renal papillary cell carcinoma protein 17 , alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog , tether, containing a UBX domain, for GLUT4

GENE ID SPEZIES
417384 Gallus gallus
495145 Xenopus laevis
691026 Rattus norvegicus
733865 Xenopus (Silurana) tropicalis
6106077 Brugia malayi
515670 Bos taurus
79058 Homo sapiens
68938 Mus musculus
Ausgewählte Anbieter für anti-ASPSCR1 (ASPSCR1) Antikörper
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