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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). Zusätzlich bieten wir Ihnen ALPL Kits (46) und ALPL Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 232 products:
Human Monoclonal ALPL Primary Antibody für FACS, ICC - ABIN4900675
Wang, Zhao, Shi, Wei, Halloran, Clark, Jacobs, Kingery: Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. in Bone 2009
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Human Monoclonal ALPL Primary Antibody für FACS - ABIN4898136
Eshel, Sharabi-Nov, Dally: Leukocyte alkaline phosphatase (LAP) by flow cytometry. in MLO: medical laboratory observer 2013
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Human Polyclonal ALPL Primary Antibody für EIA, WB - ABIN356989
Panuccio, Cutrupi, Pizzini, Mallamaci, Tripepi, Zoccali: Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study. in American journal of kidney diseases : the official journal of the National Kidney Foundation 2007
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Human Monoclonal ALPL Primary Antibody für FACS, ICC - ABIN4900651
Pytlík, Stehlík, Soukup, Kalbácová, Rypácek, Trc, Mulinková, Michnová, Kideryová, Zivný, Klener, Veselá, Trnený, Klener: The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. in Biomaterials 2009
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Human Monoclonal ALPL Primary Antibody für EIA, FACS - ABIN1105293
Kannampuzha, Tupy, Pritzker: Mercaptopyruvate inhibits tissue-nonspecific alkaline phosphatase and calcium pyrophosphate dihydrate crystal dissolution. in The Journal of rheumatology 2009
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Human Polyclonal ALPL Primary Antibody für IHC (p), WB - ABIN1105292
Fedde, Whyte: Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'-phosphate ectophosphatase: normal and hypophosphatasia fibroblast study. in American journal of human genetics 1990
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Human Monoclonal ALPL Primary Antibody für FACS, IHC - ABIN969500
Kanazawa, Yamaguchi, Yamamoto, Yamauchi, Yano, Sugimoto: Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. in Calcified tissue international 2009
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Human Monoclonal ALPL Primary Antibody für FACS - ABIN4898128
Klim, Li, Wrighton, Piekarczyk, Kiessling: A defined glycosaminoglycan-binding substratum for human pluripotent stem cells. in Nature methods 2010
Cat (Feline) Monoclonal ALPL Primary Antibody für ICC, FACS - ABIN153427
Chou, Gu, Gao, Dowey, Wang, Shi, Li, Ye, Cheng, Cheng: A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach. in Stem cells translational medicine 2015
Mouse (Murine) Polyclonal ALPL Primary Antibody für FACS, ICC - ABIN4899354
Liedert, Mattausch, Röntgen, Blakytny, Vogele, Pahl, Bindl, Neunaber, Schinke, Harroch, Amling, Ignatius: Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading. in Bone 2011
Preoperative calcitonin (zeige CALCA Antikörper) levels were correlated with the presence of tumor, whereas alkaline phosphatase (ALP) levels were not. There were no significant associations between tumor volume and ALP (zeige ALP Antikörper) or calcitonin (zeige CALCA Antikörper) levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP (zeige ALP Antikörper) was significantly associated with tumor recurrence, but serum calcitonin (zeige CALCA Antikörper) was not.
His ALPL gene mutation came from c.228delG mutation in his mother and c.407G>A compound heterozygous mutation in his father
Both PPARgamma (zeige PPARG Antikörper) gene expression and TNALP activity increased during intracellular lipid accumulation in HepG2 and 3T3-L1 cells. Inhibition of TNALP blocked intracellular lipid accumulation but did not alter expression of the PPARgamma (zeige PPARG Antikörper) gene.
ALPL is a major contributor to the pathogenesis of Prostate cancer progression.
ALPL expression is significantly upregulated in human masticatory mucosa during wound healing
serum ALP (zeige ALP Antikörper) levels were not associated with increased death risk in prevalent HD patients over a 5-year interval.
In conclusion, serum levels of BSP (zeige KLK6 Antikörper), ALP (zeige ALP Antikörper), ICTP, and PSA (zeige PLAG1 Antikörper) increased in patients with bone metastases, and combined detection of all markers could improve the positive-predictive value.
results reveal that the amino acid substitutions at position 426 of TNSALP differentially affect the structure and function of TNSALP, leading to understanding of the molecular and cellular basis of hypophosphatasia.
One-half of adult individuals with unexplained low serum ALP (zeige ALP Antikörper) carried an ALPL mutation. The presence of a mutated allele was associated with tooth loss, slightly lower levels of serum ALP (zeige ALP Antikörper), higher levels of pyridoxal phosphate and phosphoethanolamine, as well as mildly increased serum phosphate.
Dynamic changes of ALP (zeige ALP Antikörper), LDH and PSA (zeige PLAG1 Antikörper) during Abiraterone-therapy are associated with best clinical benefit and OS in bone metastatic castration resistant prostate cancer
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (zeige MBD4 Antikörper) plays role in enamel formation; Med1 (zeige MBD4 Antikörper) induces Alpl via stimulation of Notch1 (zeige NOTCH1 Antikörper) signaling by forming Notch1 (zeige NOTCH1 Antikörper)-RBP-Jk (zeige RBPJ Antikörper) complex on Alpl promoter. (Med1 (zeige MBD4 Antikörper) = mediator complex subunit 1 (zeige MED1 Antikörper); Alpl = alkaline phosphatase, liver-bone-kidney; Notch1 (zeige NOTCH1 Antikörper) = Notch gene homolog 1 (zeige NOTCH1 Antikörper); RBP-Jk (zeige RBPJ Antikörper) = kappa J region recombining binding protein suppressor of hairless (zeige RBPJ Antikörper))
These analyses revealed that TNAP deficient mice present an increased proliferation of neural precursors, an altered neuronal morphology, and an augmented neuronal activity. We found that these alterations were associated with a partial downregulation of the purinergic P2X7 receptor (P2X7R (zeige P2RX7 Antikörper)).
Despite similar deficiencies in alkaline phosphatase, Alpl(-/-) mice develop craniosynostosis and a brachycephalic/acrocephalic craniofacial shape of variable penetrance.
Prevention of lethal murine hypophosphatasia by neonatal ex vivo gene therapy using lentivirally transduced bone marrow cells expressing Akp-2.
TNAP in the vasculature contributes to the pathology of medial vascular calcification and that it is a druggable target.
In cardiac fibroblasts, TNAP expression and activity is induced by sFRP2 (zeige SFRP2 Antikörper).
p107 (zeige RBL1 Antikörper) is required for the efficient recruitment of an activating SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) chromatin-remodeling complex, an essential event in Alpl induction.
Inhibition of rhBMP-2-induced ALP (zeige CCL21A Antikörper) activity by intracellular delivery of SMURF1 (zeige SMURF1 Antikörper) in murine calvarial preosteoblast cells.
Findings demonstrate that Alpl(-/-) mice exhibit a craniofacial skeletal phenotype similar to that seen in infants with HPP (zeige HPR Antikörper), including true bony craniosynostosis in the context of severely diminished bone mineralization
CD73 and TNAP play interactive roles to metabolize luminally applied 5'-AMP (zeige TMPRSS5 Antikörper) in the renal vasculature such that inhibition of both is required to inhibit the production of adenosine.
The peri (zeige PLIN1 Antikörper)-partum characteristics of serum bone-specific alkaline phosphatase (BAP (zeige PHB2 Antikörper)) and urinary deoxypyridinoline (DPD (zeige DPYD Antikörper)) in dairy cattle are reported.
GPI (zeige GPI Antikörper)-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization\; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
tissue-nonspecific alkaline phosphatase
, alkaline phosphatase, tissue-nonspecific isozyme
, tissue non-specific alkaline phosphatase
, alkaline phosphatase, liver/bone/kidney
, alkaline phosphatase, tissue-nonspecific isozyme-like
, alkaline phosphatase liver/bone/kidney isozyme
, alkaline phosphomonoesterase
, liver/bone/kidney-type alkaline phosphatase
, tissue-nonspecific ALP
, alkaline phosphatase 2, liver
, Tissue-nonspecific ALP alkaline phosphatase
, alkaline phosphatase tissue non-specific isoform
, liver/bone/kidney isozyme