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The protein encoded by AHCYL1 interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Zusätzlich bieten wir Ihnen AHCYL1 Proteine (5) und AHCYL1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 38 products:
Human Polyclonal AHCYL1 Primary Antibody für ELISA, WB - ABIN564694
Yamaguchi, Ishikawa: IRBIT reduces the apparent affinity for intracellular Mg²? in inhibition of the electrogenic Na?-HCO?? cotransporter NBCe1-B. in Biochemical and biophysical research communications 2012
Human Monoclonal AHCYL1 Primary Antibody für IHC (p), ELISA - ABIN564695
Scicchitano, Dalmas, Boyce, Thomas, Frazier: Protein extraction of formalin-fixed, paraffin-embedded tissue enables robust proteomic profiles by mass spectrometry. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009
IRBIT forms signaling complexes with PIPKIalpha and NBCe1 (zeige SLC4A4 Antikörper)-B, whose activity is regulated by PI(4,5)P2.
Formation of the Ribonucleotide reductase-IRBIT complex is regulated through phosphorylation of IRBIT, and ablation of IRBIT expression in HeLa cells causes imbalanced dNTP pools and altered cell cycle progression.
IRBIT is a master regulator of ion channels and ion transporters. (Review)
IRBIT plays an important role in intracellular pH regulation, mediated by NHE3 (zeige SLC9A3 Antikörper), and further regulated by SPAK (zeige STK39 Antikörper).
relationships between the WNK/SPAK (zeige STK39 PLURAL_@12787@) and IRBIT/PP1 (zeige PPA1 PLURAL_@12787@) sites in the regulation of Na+-HCO3- cotransporters
conclude that AHCYL1 expression is associated with ovarian carcinogenesis as an oncogene (zeige RAB1A Antikörper) in chickens, whereas it plays the role of tumor suppressor in human EOC, suggesting a paradoxical function of AHCYL1 in ovarian carcinogenesis
A NBCe1 (zeige SLC4A4 Antikörper)-B construct that lacks amino acid residues 2-16 of the amino-terminus is fully autoinhibited, but cannot be stimulated by IRBIT, indicating that autoinhibitory and IRBIT-binding determinants within the cytosolic amino-terminus are not identical.
Both IRBIT (inositol 1,4,5-trisphosphate receptor-binding protein) and WNK [with no lysine (K)] kinase have been implicated as additional HCO(3)(-) secretory controllers.
IRBIT opposes the effects of WNKs and SPAK (zeige STK39 Antikörper) by recruiting PP1 (zeige PPA1 Antikörper) to the complex to dephosphorylate CFTR (zeige CFTR Antikörper) and NBCe1 (zeige SLC4A4 Antikörper)-B, restoring their cell surface expression, in addition to stimulating their activities
IRBIT is critically involved in mediating activation of NHE3 (zeige SLC9A3 PLURAL_@27095@) by ANG II (zeige AGT PLURAL_@27095@) via a Ca(2 (zeige CA2 PLURAL_@27095@)+)/calmodulin (zeige CALM1 PLURAL_@27095@)-dependent protein kinases II-dependent pathway.
AHCYL1 has a different function from AHCY (zeige AHCY Antikörper) and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
NHERF1 (zeige SLC9A3R2 Antikörper) mediates ANG II (zeige AGT Antikörper)-induced activation of renal NHE3 (zeige SLC9A3 Antikörper), which requires coordination between IRBIT and the NHERF1 (zeige SLC9A3R2 Antikörper) PDZ1 domain in binding and transporting NHE3 (zeige SLC9A3 Antikörper)
IRBIT suppresses CaMKIIalpha (zeige CAMK2 Antikörper) activity and contributes to catecholamine homeostasis through TH phosphorylation.
Irbit was sequestered by InsP3 receptors (IP3Rs) in the endoplasmic reticulum
IRBIT opposes the effects of WNKs and SPAK (zeige STK39 Antikörper) by recruiting PP1 (zeige PPP1CC Antikörper) to the complex to dephosphorylate CFTR (zeige CFTR Antikörper) and NBCe1 (zeige SLC4A4 Antikörper)-B, restoring their cell surface expression, in addition to stimulating their activities
IRBIT can directly interact with the IP3R (zeige ITPR1 Antikörper), and that both the suppressor domain and the IP3-binding core of the IP3R (zeige ITPR1 Antikörper) are essential for a strong interaction.
phosphorylation of Ser71 and Ser74 were sufficient to enable inhibition of IP3 binding to the IP3R (zeige ITPR1 Antikörper) by IRBIT
Data show that pNBC1 activation requires the IRBIT PEST domain, while CFTR (zeige CFTR Antikörper) activation requires multiple domains, and suggest that IRBIT is a key coordinator of epithelial fluid and HCO3- secretion.
Results sugest that IRBIT modulates the polyadenylation state of specific mRNAs, both by controlling the cytoplasmic/nuclear partitioning of Fip1 (zeige RRAGA Antikörper) and by inhibiting PAP (zeige ASAP1 Antikörper) activity, in response to a stimulus that alters its phosphorylation state.
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene.
, putative adenosylhomocysteinase 2-like
, S-adenosylhomocysteine hydrolase-like 1
, putative adenosylhomocysteinase 2
, DC-expressed AHCY-like molecule
, S-adenosyl homocysteine hydrolase homolog
, S-adenosyl-L-homocysteine hydrolase 2
, S-adenosylhomocysteine hydrolase-like protein 1
, adoHcyase 2
, dendritic cell expressed AHCY-like protein
, inositol 1,4,5-trisphosphate receptor-binding protein
, IP3R binding protein released with inositol 1,4,5-trisphosphate
, IP3R-binding protein released with inositol 1,4,5-trisphosphate
, S-adenosylhomocysteine hydrolase, related sequence 3