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S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. Zusätzlich bieten wir Ihnen AHCY Proteine (95) und AHCY Kits (21) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 110 products:
Human Monoclonal AHCY Primary Antibody für ELISA, WB - ABIN513196
Fernandez-Sanchez, Gonatopoulos-Pournatzis, Preston, Lawlor, Cowling: S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation. in Molecular and cellular biology 2009
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Human Polyclonal AHCY Primary Antibody für IF (p), IHC (p) - ABIN708611
Huang, Huan, Liu: A comparative proteomic analysis reveals important proteins for the fertilization and early embryonic development of the oyster Crassostrea gigas. in Proteomics 2016
Human Monoclonal AHCY Primary Antibody für ELISA, WB - ABIN559816
Kim, Kang, Lee, Lee, Yu, Kim, Lee: Identification of S100A8 and S100A9 as serological markers for colorectal cancer. in Journal of proteome research 2009
Human Polyclonal AHCY Primary Antibody für IHC - ABIN965520
Yuan, Borchardt: Photoaffinity labeling of human placental S-adenosylhomocysteine hydrolase with [2-3H]8-azido-adenosine. in The Journal of biological chemistry 1995
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In order to enable the development of small molecule AHCY inhibitors as targeted cancer therapeutics we developed an assay based on a RapidFire high-throughput mass spectrometry detection system, which allows the direct measurement of AHCY enzymatic activity.
SAH (zeige ACSM3 Antikörper) hydrolase deficiency can remain asymptomatic in childhood, and the disorder can be associated with early onset hepatocellular carcinoma.
H19 (zeige NCKAP1 Antikörper) knockdown activates SAHH, leading to increased DNMT3B (zeige DNMT3B Antikörper)-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19 (zeige NCKAP1 Antikörper)-Nctc1 locus.
S-adenosylhomocysteine hydrolase is regulated by lysine acetylation
SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus.
A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples.
Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment.
SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells
In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range.
We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH (zeige ACSM3 Antikörper), declination of SAM (zeige TTN Antikörper) and SAM (zeige TTN Antikörper)/SAH (zeige ACSM3 Antikörper) ratio and reduced expression of SAHH and MBD2 (zeige DPEP2 Antikörper), but increased activity of DNMT3a (zeige DNMT3A Antikörper) and DNMT3b (zeige DNMT3B Antikörper) affecting DNA methylation (zeige HELLS Antikörper)
Ahcy was identified from coupling of methylation with gene expression data, shed light on the underlying mechanisms of cytosine demethylation under methyl-deficient conditions.
report the crystallization of mouse SAHH in the presence of the reaction product adenosine. The crystals diffracted to at least 1.55 A degrees resolution and are suitable for X-ray structure analysis at high resolution.
report that Myc (zeige MYC Antikörper) promotes upregulation of S-adenosyl homocysteine hydrolase.
AHCYL1 (zeige AHCYL1 Antikörper) has a different function from AHCY and plays an important role in embryogenesis by modulating inositol 1,4,5-trisphosphate receptor function for the intracellular calcium release
Hepatic steatosis and liver degeneration are prominent features of the ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy).
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, S-adenosyl-L-homocysteine hydrolase
, S-adenosyl-L-homocysteine hydrolase B
, adenosylhomocysteinase B
, adoHcyase B
, liver copper-binding protein