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AMPD3 encodes a member of the AMP deaminase gene family. Zusätzlich bieten wir Ihnen AMPD3 Antikörper (69) und AMPD3 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
mtDNA deletion coordinately induces AMP (zeige APRT ELISA Kits) deaminase to contribute to the loss of atrial adenine nucleotides through degrading AMP (zeige APRT ELISA Kits) excessively.
The primary underlying mechanism for increased catabolic flow through the AMP (zeige APRT PLURAL_@27096@) deaminase reaction in circulating erythrocytes of individuals with familial phosphofructokinase deficiency is Ca2 (zeige CA2 PLURAL_@27096@)+-calmodulin (zeige CALM1 PLURAL_@27096@) activation of AMP deaminase isoform E.
may control the systemic metabolic status by changing AMPK (zeige PRKAA1 ELISA Kits) activity through the AMP (zeige APRT ELISA Kits) level.
This is a first report evidencing the pattern of AMPD (zeige AMPD1 ELISA Kits) genes expression in neoplastic human liver.
Data show that AMP deaminase 3 (Ampd3)-/-/5'-nucleotidase (CD73)-/- knockout mice are more sensitive to AMP (zeige TMPRSS5 ELISA Kits)-induced hypometabolism than mice with a single enzyme deficiency, which are more sensitive than wild type.
depletion of the epigenome modifier histone deacetylase 3 (HDAC3 (zeige HDAC3 ELISA Kits)) specifically in skeletal muscle causes severe systemic insulin (zeige INS ELISA Kits) resistance in mice but markedly enhances endurance and resistance to muscle fatigue, despite reducing muscle force. This is due to lower glucose utilization and greater lipid oxidation in HDAC3 (zeige HDAC3 ELISA Kits)-depleted muscles, a fuel switch caused by the activation of anaplerotic reactions driven by Ampd3.
Mice carrying the mutation exhibit rapid RBC (zeige CACNA1C ELISA Kits) turnover, with increased erythropoiesis, dramatically shortened RBC (zeige CACNA1C ELISA Kits) lifespan, and signs of increased RBC (zeige CACNA1C ELISA Kits) senescence/eryptosis, suggesting a key role for AMPD3 in determining RBC (zeige CACNA1C ELISA Kits) half-life. Mice were also found to be resistant to infection with the rodent malaria Plasmodium chabaudi.
Erythrocytes from Ampd3(-/-) mice exhibited higher half-saturation pressure of oxygen.
effect of AMP-deaminase 3 knock-out in mice on enzyme activity in heart and other organs
AMP (zeige TMPRSS5 ELISA Kits) deaminase-deficient models demonstrate for the first time that AMPD3 plays a critical role in remote reperfusion lung injury via generation of inosine monophosphate (IMP (zeige BRAP ELISA Kits)).
AMPD3 deficiency increases the level of ATP in erythrocytes, but does not improve anemia due to pyruvate kinase deficiency and leads to erythrocyte dysfunction.
Along with the activation of AMPD3, ischemia-reperfusion-induced lung inflammation is associated with increased MPO (zeige MPO ELISA Kits) activity and TNF-alpha (zeige TNF ELISA Kits) level.
This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
adenosine monophosphate deaminase (isoform E)
, AMP deaminase 3
, adenosine monophosphate deaminase 3
, erythrocyte adenosine monophosphate deaminase
, AMP deaminase 3-like
, AMP aminohydrolase
, erythrocyte AMP deaminase
, erythrocyte type AMP deaminase
, erythrocyte-specific AMP deaminase
, myoadenylate deaminase
, AMP deaminase H-type
, heart-type AMPD