anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antikörper

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Zusätzlich bieten wir Ihnen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
APPL2 362860  
APPL2 55198 Q8NEU8
APPL2 216190 Q8K3G9
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Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antikörper auf antikoerper-online.de

Showing 10 out of 33 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of APPL2 Antibody (N-term) Pab  pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. APPL2 Antibody (N-term) (arrow) was detected using the purified Pab. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert WB Western Blot: DIP13B Antibody [NBP2-16165] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIP13B Antibody [NBP2-16164] - Immunohistochemical analysis of paraffin-embedded HBL435 xenograft, using antibody at 1:100 dilution. Western Blot: DIP13B Antibody [NBP2-16164] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Maus Unkonjugiert IF, WB Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 MaxPab polyclonal antibody.Lane 1: APPL2 transfected lysate(73.04 KDa).Lane 2: Non-transfected lysate. APPL2 MaxPab polyclonal antibody. Western Blot analysis of APPL2 expression in rat brain. 50 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIP13B Antibody [NBP2-14303] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. Western Blot: DIP13B Antibody [NBP2-14303] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY413268) 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Maus Unkonjugiert IF, ELISA, WB Detection limit for recombinant GST tagged APPL2 is 0.3 ng/ml as a capture antibody. Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 monoclonal antibody (M06), clone 1C10.Lane 1: APPL2 transfected lysate (Predicted MW: 74.5 KDa).Lane 2: Non-transfected lysate. 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
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Human Kaninchen Unkonjugiert ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
941,11 €
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Human Kaninchen HRP ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
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Human Kaninchen Biotin ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
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Human Kaninchen PE ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
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APPL2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Rat (Rattus) ,
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Human ,
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Mouse (Murine) ,


Am meisten referenzierte anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antikörper

  1. Human Polyclonal APPL2 Primary Antibody für IF, WB - ABIN527414 : Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. in The Journal of endocrinology 2011 (PubMed)

Weitere Antikörper gegen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Interaktionspartner

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Interaktionspartner

  1. Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 (zeige APLP2 Antikörper) gene provides a putative colorectal neoplasm progression index.

  2. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  3. ATM (zeige ATM Antikörper) is the central modulator of APPL (zeige APPL1 Antikörper)-mediated effects on radiosensitivity and DNA repair.

  4. It concludes that APPL2 (zeige APLP2 Antikörper)(PH) binding to BAR domain and Reptin (zeige RUVBL2 Antikörper) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (zeige RUVBL2 Antikörper).

  5. C-APPL1 (zeige APPL1 Antikörper)/A-APPL2 (zeige APLP2 Antikörper) allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin (zeige ADIPOQ Antikörper) cytoprotective effect on liver.

  6. Data indicate that a high level of APPL2 (zeige APLP2 Antikörper) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  7. analysis of APPL1 (zeige APPL1 Antikörper) and APPL2 (zeige APLP2 Antikörper) proteins and their interaction with Rab (zeige HRB Antikörper)

  8. Genetic variation(s) in APPL1 (zeige APPL1 Antikörper)/2 may be associated with CAD (zeige CAD Antikörper) risk in T2DM in Chinese population.

  9. Data suggest that although annexin A2 (zeige ANXA2 Antikörper) is not an exclusive marker of APPL1 (zeige APPL1 Antikörper)/2 endosomes, it has an important function in membrane recruitment of APPL (zeige APPL1 Antikörper) proteins, acting in parallel to Rab5 (zeige RAB5A Antikörper).

  10. significant fluorescence resonance energy transfer between APPL (zeige APPL1 Antikörper) minimal BAR domain FRET pairs

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Interaktionspartner

  1. Appl1 (zeige APPL1 Antikörper)/2-null mouse embryonic fibroblasts exhibited defects in HGF (zeige HGF Antikörper)-induced Akt (zeige AKT1 Antikörper) activation, migration, and invasion.

  2. Rab31 (zeige RAB31 Antikörper), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (zeige AKT1 Antikörper) signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antigen-Profil

Protein Überblick

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Genbezeichner und Symbole assoziert mit APPL2

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) Antikörper
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2) Antikörper
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) Antikörper
  • amyloid beta (A4) precursor-like protein 2 (APLP2) Antikörper
  • APPL2 Antikörper
  • Dip3b Antikörper
  • DIP13B Antikörper
  • MGC84621 Antikörper
  • RGD1563028 Antikörper

Bezeichner auf Proteinebene für APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPEZIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
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