Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteine (APPL1)

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Zusätzlich bieten wir Ihnen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antikörper (67) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
Ratte APPL1 APPL1 290537  
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Top Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteine auf antikoerper-online.de

Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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APPL1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartnern

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartner

  1. APPL1 positively mediated leptin (zeige LEP Proteine) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (zeige RAB5A Proteine) overactivation through beta-cleaved carboxy-terminal fragment of APP (zeige APP Proteine)-APPL1 interactions constitutes a novel APP (zeige APP Proteine)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (zeige RAB5A Proteine)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (zeige TLR3 Proteine)/4-dependent TBK1 (zeige TBK1 Proteine) and IKKepsilon (zeige IKBKE Proteine) activation in macrophages.

  10. ATM (zeige ATM Proteine) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartner

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (zeige HGF Proteine)-induced Akt (zeige AKT1 Proteine) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (zeige PRKAA1 Proteine) signaling.

  3. A role for APPL1 in TLR3 (zeige TLR3 Proteine)/4-dependent TBK1 (zeige TBK1 Proteine) and IKKepsilon (zeige IKBKE Proteine) activation in macrophages.

  4. APPL1 sensitizes insulin (zeige INS Proteine) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (zeige INS Proteine) signaling and crosstalk between the insulin (zeige INS Proteine) and adiponectin (zeige ADIPOQ Proteine) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (zeige INS Proteine) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (zeige INS Proteine) resistance and improves adipoR1 (zeige ADIPOR1 Proteine)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (zeige AKT1 Proteine) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (zeige INS Proteine) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Protein Überblick

Protein Überblick

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Genbezeichner und Symbole assoziert mit APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1)
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1)
  • 2900057D21Rik Protein
  • 7330406P05Rik Protein
  • AI585782 Protein
  • APPL Protein
  • AW209077 Protein
  • BB022931 Protein
  • C88264 Protein
  • DIP13 Protein
  • DIP13alpha Protein
  • RGD1309388 Protein

Bezeichner auf Proteinebene für APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPEZIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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