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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) ELISA Kits

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Zusätzlich bieten wir Ihnen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antikörper (62) und Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human APPL1 APPL1 26060 Q9UKG1
Anti-Maus APPL1 APPL1 72993 Q8K3H0
Anti-Ratte APPL1 APPL1 290537  
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Weitere ELISA Kits für Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Interaktionspartner

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartner

  1. Results indicate that persistent rab5 (zeige RAB5A ELISA Kits) overactivation through beta-cleaved carboxy-terminal fragment of APP (zeige APP ELISA Kits)-APPL1 interactions constitutes a novel APP (zeige APP ELISA Kits)-dependent pathogenic pathway in Alzheimer's disease

  2. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  3. Low expression of APPL1 is associated with metastasis in prostate cancer.

  4. APPL1 endosomes represent a distinct population of Rab5 (zeige RAB5A ELISA Kits)-positive sorting endosomes.

  5. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (zeige TSC2 ELISA Kits)

  6. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  7. A role for APPL1 in TLR3 (zeige TLR3 ELISA Kits)/4-dependent TBK1 (zeige TBK1 ELISA Kits) and IKKepsilon (zeige IKBKE ELISA Kits) activation in macrophages.

  8. ATM (zeige ATM ELISA Kits) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  9. APPL1 sensitizes insulin (zeige INS ELISA Kits) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (zeige INS ELISA Kits) signaling and crosstalk between the insulin (zeige INS ELISA Kits) and adiponectin (zeige ADIPOQ ELISA Kits) pathways.

  10. APPL1 is a positive regulator of Dvl2 (zeige DVL2 ELISA Kits)-dependent transcriptional activity of AP-1 (zeige FOSB ELISA Kits).

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaktionspartner

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (zeige HGF ELISA Kits)-induced Akt (zeige AKT1 ELISA Kits) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (zeige PRKAA1 ELISA Kits) signaling.

  3. A role for APPL1 in TLR3 (zeige TLR3 ELISA Kits)/4-dependent TBK1 (zeige TBK1 ELISA Kits) and IKKepsilon (zeige IKBKE ELISA Kits) activation in macrophages.

  4. APPL1 sensitizes insulin (zeige INS ELISA Kits) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (zeige INS ELISA Kits) signaling and crosstalk between the insulin (zeige INS ELISA Kits) and adiponectin (zeige ADIPOQ ELISA Kits) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (zeige INS ELISA Kits) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (zeige INS ELISA Kits) resistance and improves adipoR1 (zeige ADIPOR1 ELISA Kits)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (zeige AKT1 ELISA Kits) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (zeige INS ELISA Kits) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Genbezeichner und Symbole assoziert mit APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) Antikörper
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) Antikörper
  • 2900057D21Rik Antikörper
  • 7330406P05Rik Antikörper
  • AI585782 Antikörper
  • APPL Antikörper
  • AW209077 Antikörper
  • BB022931 Antikörper
  • C88264 Antikörper
  • DIP13 Antikörper
  • DIP13alpha Antikörper
  • RGD1309388 Antikörper

Bezeichner auf Proteinebene für APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPEZIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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