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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Zusätzlich bieten wir Ihnen Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 64 products:
Mouse (Murine) Monoclonal APPL1 Primary Antibody für ICC, IF - ABIN1042584
Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. in Oncogene 1999
Zeige alle 5 Referenzen für ABIN1042584
Cow (Bovine) Polyclonal APPL1 Primary Antibody für WB - ABIN374837
Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. in Nature cell biology 2006
Human Polyclonal APPL1 Primary Antibody für WB - ABIN2785912
McCrea, Paradise, Tomasini, Addis, Melis, De Matteis, De Camilli: All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding. in Biochemical and biophysical research communications 2008
Human Polyclonal APPL1 Primary Antibody für ELISA, WB - ABIN1451205
Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007
Results indicate that persistent rab5 (zeige RAB5A Antikörper) overactivation through beta-cleaved carboxy-terminal fragment of APP (zeige APP Antikörper)-APPL1 interactions constitutes a novel APP (zeige APP Antikörper)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (zeige RAB5A Antikörper)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (zeige TSC2 Antikörper)
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (zeige TLR3 Antikörper)/4-dependent TBK1 (zeige TBK1 Antikörper) and IKKepsilon (zeige IKBKE Antikörper) activation in macrophages.
ATM (zeige ATM Antikörper) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.
APPL1 sensitizes insulin (zeige INS Antikörper) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (zeige INS Antikörper) signaling and crosstalk between the insulin (zeige INS Antikörper) and adiponectin (zeige ADIPOQ Antikörper) pathways.
APPL1 is a positive regulator of Dvl2 (zeige DVL2 Antikörper)-dependent transcriptional activity of AP-1 (zeige FOSB Antikörper).
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (zeige HGF Antikörper)-induced Akt (zeige AKT1 Antikörper) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (zeige PRKAA1 Antikörper) signaling.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (zeige INS Antikörper) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (zeige INS Antikörper) resistance and improves adipoR1 (zeige ADIPOR1 Antikörper)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (zeige AKT1 Antikörper) cascade in neurons.
Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (zeige INS Antikörper) resistance to beta-cell dysfunction in type 2 diabetes.
Endurance training was able to increase APPL1 expression.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like