anti-Activin Receptor Type I (ACRV1) Antikörper

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Zusätzlich bieten wir Ihnen Activin Receptor Type I Proteine (35) und Activin Receptor Type I Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ACRV1 11477 P37172
ACRV1 90 Q04771
ACRV1 79558 P80201
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Top anti-Activin Receptor Type I Antikörper auf antikoerper-online.de

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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit <br /> Target Name: ACVR1 <br /> Sample Tissue: Human Fetal Heart <br /> Antibody Dilution: 1.0 µg/mL Host: Rabbit <br /> Target Name: ACVR1 <br /> Sample Tissue: Human Fetal Lung <br /> Antibody Dilution: 1.0 µg/mL 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-ACVR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate Immunohistochemistry with Kidney tissue at an antibody concentration of 5µg/ml using anti-ACVR1 antibody (ARP45040_P050) 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB The anti-ACVR1 Pab (ABIN392240) is used in Western blot to detect ACVR1 in HeLa cell lysate (Lane 1) and mouse liver tissue lysate (Lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center N153) (ABIN391154). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR1 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of anti-ACVR1 Pab (ABIN391155) in mouse brain tissue lysate.ACVR1(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of anti-ACVR1 Pab (ABIN391156) in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center) (ABIN657777). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1 gene. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate.ACVR1(arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

ACRV1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Activin Receptor Type I Antikörper

  1. Human Polyclonal ACRV1 Primary Antibody für IHC (p), WB - ABIN392240 : ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. in Oncogene 1993 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal ACRV1 Primary Antibody für CyTOF, FACS - ABIN4899715 : Fujimoto, Ohte, Shin, Yoneyama, Osawa, Miyamoto, Tsukamoto, Mizuta, Kokabu, Machiya, Okuda, Suda, Katagiri: Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2. in Biochemical and biophysical research communications 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal ACRV1 Primary Antibody für IHC (p), IHC - ABIN256737 : Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. in Nature genetics 2006 (PubMed)

Weitere Antikörper gegen Activin Receptor Type I Interaktionspartner

Mouse (Murine) Activin Receptor Type I (ACRV1) Interaktionspartner

  1. Acute tacrolimus treatment transiently increases hepcidin (zeige HAMP Antikörper) in wild-type mice. FKBP12 (zeige FKBP1A Antikörper) preferentially targets the BMP receptor (zeige BMPR1A Antikörper) ALK2. ALK2 mutants defective in binding FKBP12 (zeige FKBP1A Antikörper) increase hepcidin (zeige HAMP Antikörper) expression in a ligand-independent manner, through BMP-SMAD (zeige SMAD1 Antikörper) signaling.

  2. The authors demonstrated that ubiquitin-specific protease (USP) 4 (zeige USP4 Antikörper) strongly induces activin (zeige Actbeta Antikörper)/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (zeige SMAD4 Antikörper).

  3. Enhanced SMAD (zeige SMAD1 Antikörper)-dependent BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice, via medial-edge-epithelium persistence presumably due to the up regulation of DeltaNp63 andresultingreductionofcaspase-3 activation. 2.

  4. BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A (zeige BMPR1A Antikörper), and BMPR2 (zeige BMPR2 Antikörper) is an essential proangiogenic cue for retinal vessels.

  5. This study showed that Gja1 (zeige GJA1 Antikörper) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 on the differentiation of uterine stromal cells through targeting Hand2 (zeige HAND2 Antikörper).

  6. Results showed activin (zeige Actbeta Antikörper)-C and follistatin (zeige FST Antikörper) are differentially expressed during prostate development and suggested that the antagonistic property of follistatin (zeige FST Antikörper) is secondary to the action of activin (zeige Actbeta Antikörper)-C. Study provides evidence to support a role of activin (zeige Actbeta Antikörper)-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.

  7. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling

  8. Suggest that BMP signaling upregulates the calcineurin/nuclear factor of activated T cell (zeige NFATC3 Antikörper) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

  9. results suggest that ACVR1(R206H) causes FOP (zeige CHTOP Antikörper) by gaining responsiveness to the normally antagonistic ligand activin A (zeige INHBA Antikörper), demonstrating that this ligand is necessary and sufficient for driving HO in a genetically accurate model of FOP (zeige CHTOP Antikörper)

  10. The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2.

Human Activin Receptor Type I (ACRV1) Interaktionspartner

  1. the Fibrodysplasia Ossificans Progressiva mutation ACVR1(R206H) is more sensitive to a number of natural ligands.

  2. both bone morphogenetic protein 2 (BMP2 (zeige BMP2 Antikörper)) and BMP6 (zeige BMP6 Antikörper) are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3 (zeige BMPR1A Antikörper)) and ALK2, play crucial and distinct roles in this process.

  3. Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1. Developed is a simplified one-step procedure by simultaneously introducing reprogramming and gene-editing components into human fibroblasts derived from patient with FOP. The one-step-mediated ALK2 gene-corrected induced pluripotent stem cells restored global gene expression pattern.

  4. The ACVR1 R206H mutation may not directly increase the formation of mature chondrogenic or osteogenic cells.

  5. Authors demonstrated that the BMP type I receptor ALK-2 (encoded by the ACVR1 gene) has crucial roles in apoptosis induction of patient-derived glioma-initiating cells (GICs), TGS (zeige LIN9 Antikörper)-01 and TGS (zeige LIN9 Antikörper)-04.

  6. Data suggest BMP9/GDF2 (zeige GDF2 Antikörper) and BMP10 (zeige BMP10 Antikörper) synergize with TNFA (zeige TNF Antikörper) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase (zeige CDK7 Antikörper) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 (zeige GDF2 Antikörper) = growth differentiation factor 2 (zeige GDF2 Antikörper); BMP10 (zeige BMP10 Antikörper) = bone morphogenetic protein 10 (zeige BMP10 Antikörper); TNFA (zeige TNF Antikörper) = tumor necrosis factor alpha (zeige TNF Antikörper); ALK2/ACVR1 = activin A receptor type 1)

  7. The effects of ACVR1/ALK2 mutations causing fibrodysplasia ossificans progressiva are extended to the central nervous system. Brainstem hamartomatous lesions and dysmorphisms, variably associated with dentate nucleus and basal ganglia signal abnormalities and/or calcifications, may represent useful disease hallmarks.

  8. Low ALK2 expression is associated with invasiveness of breast cancer.

  9. Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6 (zeige BMP6 Antikörper), ALK2 and BMPRII (zeige BMPR2 Antikörper) had deeper growth than tumors with only BMP6 (zeige BMP6 Antikörper) expression

  10. The clinical manifestations, the disease course, and the molecular findings of involvement of ACVR1 gene in this family are suggestive of "FOP variant" or an unusual ACVR1-related skeletal dysplasia

Activin Receptor Type I (ACRV1) Antigen-Profil

Protein Überblick

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Genbezeichner und Symbole assoziert mit ACRV1

  • activin A receptor, type 1 (Acvr1) Antikörper
  • activin A receptor type 1 (ACVR1) Antikörper
  • activin A receptor type 1 (Acvr1) Antikörper
  • ActR-I Antikörper
  • ActR-IA Antikörper
  • ACTRI Antikörper
  • ActRIA Antikörper
  • Acvr Antikörper
  • ACVR1A Antikörper
  • ACVRLK2 Antikörper
  • Alk-2 Antikörper
  • ALK2 Antikörper
  • Alk8 Antikörper
  • D330013D15Rik Antikörper
  • FOP Antikörper
  • SKR1 Antikörper
  • Tsk7L Antikörper
  • TSRI Antikörper

Bezeichner auf Proteinebene für ACRV1

TGF-B superfamily receptor type I , TSK-7L , TSR-I , activin receptor type I , activin receptor type-1 , serine/threonine-protein kinase receptor R1 , activin A receptor, type II-like kinase 2 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , ACTR-I , SKR1 , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA

GENE ID SPEZIES
11477 Mus musculus
90 Homo sapiens
478757 Canis lupus familiaris
338068 Bos taurus
79558 Rattus norvegicus
395246 Gallus gallus
443161 Ovis aries
Ausgewählte Anbieter für anti-Activin Receptor Type I (ACRV1) Antikörper
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