anti-Abhydrolase Domain Containing 12 (ABHD12) Antikörper

ABHD12 encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. Zusätzlich bieten wir Ihnen ABHD12 Proteine (8) und ABHD12 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ABHD12 76192 Q99LR1
ABHD12 499913 Q6AYT7
ABHD12 26090 Q8N2K0
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Top anti-ABHD12 Antikörper auf antikoerper-online.de

Showing 10 out of 55 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-ABHD12 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Human Spleen 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from COLO cells, using ABHD12 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of ABHD12 Antibody (N-term) (ABIN652851) in mouse cerebellum tissue lysates (35 µg/lane). ABHD12 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with ABHD12 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Maus Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Human Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Maus Ziege Unkonjugiert ELISA, WB EB08783 (0.3µg/ ml) staining of Mouse Brain lysate (35µg/ protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$326.89
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$175.80
Details
Maus Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details

ABHD12 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) ,
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Rat (Rattus) ,
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Am meisten referenzierte anti-ABHD12 Antikörper

  1. Mouse (Murine) Polyclonal ABHD12 Primary Antibody für ELISA, WB - ABIN451662 : Blankman, Simon, Cravatt: A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. in Chemistry & biology 2007 (PubMed)

Weitere Antikörper gegen ABHD12 Interaktionspartner

Mouse (Murine) Abhydrolase Domain Containing 12 (ABHD12) Interaktionspartner

  1. In mouse macrophages, disruption of ABHD12 and ABHD16A (zeige ABHD16A Antikörper) respectively increases and decreases both lysophosphatidylserines and lipopolysaccharide-induced cytokine production.

  2. FAAH (zeige FAAH Antikörper) but not monoacyl glycerol lipase (zeige LIPG Antikörper) exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage.

  3. provide a molecular model for PHARC, where disruption of ABHD12 causes deregulated LPS (zeige TLR4 Antikörper) metabolism and the accumulation of proinflammatory lipids that promote microglial and neurobehavioral abnormalities

  4. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract disease.

  5. Data reveal that 85% of brain 2 (zeige POU3F2 Antikörper)-arachidonoylglycerol hydrolase (zeige ABHD6 Antikörper) activity can be ascribed to monoacylglycerol lipase(MAGL (zeige MGLL Antikörper)), and the remaining 15% is catalyzed by ABHD6 (zeige ABHD6 Antikörper) and ABHD12.

Human Abhydrolase Domain Containing 12 (ABHD12) Interaktionspartner

  1. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems.

  2. Null mutations in the ABHD12 gene lead to PHARC syndrome, a neurodegenerative disease including polyneuropathy, hearing loss, cerebellar ataxia, RP, and early-onset cataract. Our study allowed us to report 5 new mutations in ABHD12.

  3. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function.

  4. ABHD12 mutations are not a frequent cause of ataxia at least in Southern Italy

  5. After the identification of the ABHD12 mutation in this family, one patient underwent neurological examination which revealed ataxia, but no polyneuropathy

  6. Data show that the three hydrolases are genuine MAG (zeige MAG Antikörper) lipases; medium-chain saturated MAGs were the best substrates for hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and 2-isomers of arachidonoylglycerol.

  7. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract disease.

ABHD12 Antigen-Profil

Protein Überblick

This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Genbezeichner und Symbole assoziert mit ABHD12

  • abhydrolase domain containing 12 (ABHD12) Antikörper
  • abhydrolase domain containing 12 (CC1G_02966) Antikörper
  • abhydrolase domain containing 12 (PTRG_02160) Antikörper
  • abhydrolase domain containing 12 S homeolog (abhd12.S) Antikörper
  • abhydrolase domain containing 12 (Abhd12) Antikörper
  • 1500011G07Rik Antikörper
  • 6330583M11Rik Antikörper
  • ABHD12 Antikörper
  • ABHD12A Antikörper
  • AI431047 Antikörper
  • AW547313 Antikörper
  • BEM46L2 Antikörper
  • C20orf22 Antikörper
  • dJ965G21.2 Antikörper
  • PHARC Antikörper

Bezeichner auf Proteinebene für ABHD12

abhydrolase domain containing 12 , monoacylglycerol lipase ABHD12-like , 2-arachidonoylglycerol hydrolase , abhydrolase domain-containing protein 12 , monoacylglycerol lipase ABHD12

GENE ID SPEZIES
477004 Canis lupus familiaris
744997 Pan troglodytes
6012413 Coprinopsis cinerea okayama7130
6339600 Pyrenophora tritici-repentis Pt-1C-BFP
100380988 Xenopus laevis
100449601 Pongo abelii
100466451 Ailuropoda melanoleuca
100342158 Oryctolagus cuniculus
76192 Mus musculus
499913 Rattus norvegicus
26090 Homo sapiens
768242 Bos taurus
421249 Gallus gallus
Ausgewählte Anbieter für anti-ABHD12 (ABHD12) Antikörper
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