anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) Antikörper

The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ABCC6 Kits (16) und ABCC6 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ABCC6 368 O95255
ABCC6 27421 Q9R1S7
ABCC6 81642 O88269
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Top anti-ABCC6 Antikörper auf antikoerper-online.de

Showing 10 out of 28 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged ABCC6 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
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Human Ratte Unkonjugiert IHC (fro), FACS, IF, IHC (p), WB   1 mL Anmelden zum Anzeigen 7 bis 9 Tage
462,00 €
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Human Ratte Unkonjugiert IHC (fro), IF, WB   1 mL Anmelden zum Anzeigen 7 bis 9 Tage
462,00 €
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged ABCC6 is approximately 0.03ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
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Human Ratte Unkonjugiert IHC (fro), IF, WB   1 mL Anmelden zum Anzeigen 15 bis 21 Tage
825,52 €
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Human Ratte Unkonjugiert IHC (fro), IF, IHC (p), WB   1 mL Anmelden zum Anzeigen 15 bis 21 Tage
825,52 €
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Human Ratte Unkonjugiert ICC, IHC, WB   1000 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.150,64 €
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Human Ratte Unkonjugiert ICC, IHC (fro), WB   1000 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.150,64 €
Details
Human Maus Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
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Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.11 KDa) . 50 μL Anmelden zum Anzeigen 7 bis 8 Tage
241,60 €
Details

ABCC6 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human
, ,
,
Mouse (Murine)


Rat (Rattus)


Am meisten referenzierte anti-ABCC6 Antikörper

  1. Human Monoclonal ABCC6 Primary Antibody für ELISA, WB - ABIN394570 : Zarbock, Hendig, Szliska, Kleesiek, Götting: Analysis of MMP2 promoter polymorphisms in patients with pseudoxanthoma elasticum. in Clinica chimica acta; international journal of clinical chemistry 2010 (PubMed)
    Zeige alle 5 Referenzen für 394570

  2. Human Monoclonal ABCC6 Primary Antibody für IHC (fro), IF - ABIN1105179 : Bergen, Plomp, Schuurman, Terry, Breuning, Dauwerse, Swart, Kool, van Soest, Baas, ten Brink, de Jong: Mutations in ABCC6 cause pseudoxanthoma elasticum. in Nature genetics 2000 (PubMed)
    Zeige alle 2 Referenzen für 1105179

  3. Human Monoclonal ABCC6 Primary Antibody für ELISA, WB - ABIN559915 : Pinckard, Sheehan, Schreiber: Ligand-induced formation of p55 and p75 tumor necrosis factor receptor heterocomplexes on intact cells. in The Journal of biological chemistry 1997 (PubMed)
    Zeige alle 2 Referenzen für 559915

  4. Human Monoclonal ABCC6 Primary Antibody für IHC (fro), FACS - ABIN1105178 : Scheffer, Hu, Pijnenborg, Wijnholds, Bergen, Scheper: MRP6 (ABCC6) detection in normal human tissues and tumors. in Laboratory investigation; a journal of technical methods and pathology 2002 (PubMed)
    Zeige alle 2 Referenzen für 1105178

Weitere Antikörper gegen ABCC6 Interaktionspartner

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) Interaktionspartner

  1. ABCC6 knockdown HepG2 cells show: 1) intracellular reductive stress; 2) cell cycle arrest in G1 phase; 3) upregulation of p21Cip p53 (zeige TP53 Antikörper) independent; and 4) downregulation of lamin A/C (zeige LMNA Antikörper). the absence of ABCC6 profoundly changes the HepG2 phenotype, suggesting that Pseudoxanthoma elasticum syndrome is a complex metabolic disease that is not exclusively related to the absence of pyrophosphate in the bloodstream.

  2. ABCC6 deficiency can be rescued by 4-phenylbutyrate therapy in a mouse model expressing human variants

  3. Biochemical and cell biological analyses demonstrate these mutations influence multiple steps in the biosynthetic pathway, minimally altering local domain structure but adversely impacting ABCC6 assembly and trafficking. The differential impacts on local and global protein structure are consistent with hierarchical folding and assembly of ABCC6.

  4. The results suggest that a transmembrane domain is not required for transport function and that a cytosolic loop maintains ABCC6 in a targeting-competent state for the basolateral membrane and might be involved in regulating the nucleotide binding domains.

  5. The results of this study showed that mtDNA(atp6 (zeige MT-ATP6 Antikörper)) variants were actively involved in schizophrenia in some families with maternal inheritance of this

  6. Pseudoxanthoma elasticum is due to mutation of the ABCC6 gene on chromosome 16.

  7. Membrane insertion and topology of the amino-terminal domain TMD0 of multidrug-resistance associated protein 6

  8. A direct relationship between reduced ABCC6 levels and the expression of pro-mineralization genes in hepatocytes.

  9. Minimal rescue of the morpholino-induced phenotype was achieved with eight of the nine mutant human ABCC6 mRNAs tested, implying pathogenicity. This study demonstrates that the Chinese PXE population harbors unique ABCC6 mutations.

  10. Virtual screening expands this possibility to explore more compounds that can interact with ABCC6, and may aid in understanding the mechanisms leading to pseudoxanthoma elasticum

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 6 (ABCC6) Interaktionspartner

  1. bisphosphonates may be helpful for prevention of mineral deposits in Pseudoxanthoma elasticum and generalized arterial calcification of infancy caused by mutations in the ABCC6 gene.

  2. In a mouse model of CKD, ABCC6 protein expression was decreased in liver and kidney, however mRNA levels were unchanged.

  3. In the Abcc6(-/-) genotype, dermal fibroblasts actively contribute to changes that promote matrix calcification; these cells can be further modulated with time by the calcified environment, contributing to the age-dependent progression.

  4. This study showed that the expression of ABCC6 in liver is an important determinant of calcification in cardiac tissues in response to injuries

  5. Magnesium oxide reduces carotid intima media thickness in Abcc6-/- mouse model for pseudoxanthoma elasticum.

  6. Studied the role of genetic modulation and the role of diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1 (zeige ENPP1 Antikörper)(asj (zeige ARSJ Antikörper)) mice.

  7. Report lower elasticity and increased myogenic tone without major changes in agonist-dependent contraction in aged Abcc6(-/-) mouse model of pseudoxanthoma elasticum.

  8. the development of cardiac hypertrophy in the 24-month-old Abcc6(-/-) mice suggests that old pseudoxanthoma elasticum patients might be prone to developing late cardiopathy.

  9. ABCC6 is in the basolateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic circulation.

  10. A single-nucleotide polymorphism in the Abcc6 gene associates with connective tissue mineralization in mice similar to targeted models for pseudoxanthoma elasticum.

ABCC6 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.

Genbezeichner und Symbole assoziert mit ABCC6

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (ABCC6) Antikörper
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (Abcc6) Antikörper
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Abcc6) Antikörper
  • ABC34 Antikörper
  • Abcc1b Antikörper
  • ARA Antikörper
  • DCC Antikörper
  • dyscalc Antikörper
  • Dyscalc1 Antikörper
  • EST349056 Antikörper
  • GACI2 Antikörper
  • MLP1 Antikörper
  • MOAT-E Antikörper
  • MOATE Antikörper
  • Mrp6 Antikörper
  • PXE Antikörper
  • PXE1 Antikörper
  • URG7 Antikörper

Bezeichner auf Proteinebene für ABCC6

ATP-binding cassette sub-family C member 6 , anthracycline resistance-associated protein , multi-specific organic anion transporter E , multidrug resistance-associated protein 6 , ATP-binding cassette, sub-family C, member 6 , multidrug resistance-associated protein-6 , ATP-binding cassette, sub-family C (CFTR/MRP), member 6 , MLP-1 , MRP-like protein 1 , liver multidrug resistance-associated protein 6

GENE ID SPEZIES
368 Homo sapiens
27421 Mus musculus
81642 Rattus norvegicus
Ausgewählte Anbieter für anti-ABCC6 (ABCC6) Antikörper
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