ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 Proteine (ABCC1)

The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ABCC1 Antikörper (72) und ABCC1 Kits (28) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ABCC1 4363 P33527
ABCC1 17250 O35379
Ratte ABCC1 ABCC1 24565 Q8CG09
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Showing 7 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
777,14 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
962,50 €
Details

ABCC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
, ,

Weitere Proteine zu ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartnern

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. Visfatin (zeige NAMPT Proteine) increases the nuclear translocation of Akt (zeige AKT1 Proteine) and its binding with ABCC1. These data showed that visfatin (zeige NAMPT Proteine) can decrease doxorubicin sensitivity of Non-small-cell lung cancer cells via activation of Akt (zeige AKT1 Proteine)/MRP1 (zeige MDM4 Proteine).

  2. Studied hedgehog (zeige SHH Proteine) signaling effect thru ATP-binding cassette (ABC (zeige ABCB6 Proteine)) transporters in hepatoma drug sensitivity. Results suggest Hedgehog (zeige SHH Proteine) signaling transcription factor Gli-2 to be the primary regulator for drug sensitivity of hepatoma through the ABCC1 transporter.

  3. This study demonstrated that mitochondrial MRP-1 (zeige MDM4 Proteine) is expressed in the outer mitochondrial membrane and is a client protein of HSP90beta (zeige HSP90AB1 Proteine).

  4. High ABCC1 expression is associated with hepatic fibrosis.

  5. This study shows direct binding between MRP1 (zeige MDM4 Proteine) Linker 1 (L1MRP1) domain and alpha- and beta-tubulin (zeige TUBB Proteine) subunits, using a scanning peptide approach

  6. In summary, chaetominine strongly reverses drug resistance by interfering with the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/Nrf2 (zeige GABPA Proteine) signaling, resulting in reduction of MRP1 (zeige MDM4 Proteine)-mediated drug efflux and induction of Bax (zeige BAX Proteine)/Bcl-2 (zeige BCL2 Proteine)-dependent apoptosis in an ADR (zeige AKR1B1 Proteine)-resistant K562/Adr (zeige AKR1B1 Proteine) leukemia cell line.

  7. cross-talk between MRP1 (zeige MDM4 Proteine) glycosylation and phosphorylation occurs.

  8. meta-analysis results strongly suggest that MRP1 (zeige MDM4 Proteine) is overexpressed in both neurons and astrocytes of intractable epilepsy patients, inhibition of MRP1 (zeige MDM4 Proteine) may enhance antiepileptic drug efficacy by increasing local drug availability

  9. Our results show MRP1 (zeige MDM4 Proteine) as a potential biomarker of resistance to treatment with irinotecan when found in CTCs from mCRC patients.

  10. Taxus chinensis var.-mediated downregulation of MRP1 (zeige MDM4 Proteine), MDR1, and LRP (zeige RPSA Proteine) might contribute to the reversal of drug resistance in non-small cell lung cancer stem cells.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  2. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.

  3. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  4. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (zeige TPM4 Proteine) sertoli cell line.

  5. neprilysin (zeige MME Proteine) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  6. Expression of apoA-I (zeige APOA1 Proteine) or ABCA1 (zeige ABCA1 Proteine) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis

  7. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.

  8. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (zeige ABCC2 Proteine), in WT cells but not in metallothionein (zeige MT Proteine)-null cells.

  9. These results identify Mrp1 as the transporter essential for S1P (zeige S1PR1 Proteine) efflux from the endothelial cells and thus for inside-out S1P (zeige S1PR1 Proteine) signaling to P-glycoprotein at the blood-brain and blood-spinal cord barriers.

  10. investigated changes in the expression and activity of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in highly purified lung dendritic cells during aging

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) Interaktionspartner

  1. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo (zeige C9orf3 Proteine) form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.

  2. P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

ABCC1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Genbezeichner und Symbole assoziert mit ABCC1

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1)
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 1 (Abcc1)
  • ABC29 Protein
  • ABCC Protein
  • Abcc1a Protein
  • Abcc1b Protein
  • Avcc1a Protein
  • GS-X Protein
  • Mdrap Protein
  • Mrp Protein
  • Mrp1 Protein

Bezeichner auf Proteinebene für ABCC1

ATP-binding cassette transporter variant ABCC1delta-ex13 , ATP-binding cassette transporter variant ABCC1delta-ex13&14 , ATP-binding cassette transporter variant ABCC1delta-ex25 , ATP-binding cassette transporter variant ABCC1delta-ex25&26 , LTC4 transporter , leukotriene C(4) transporter , multidrug resistance-associated protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1b , multiple drug resistance-associated protein , ATP-binding cassette sub-family C member 1 , multidrug resistance protein 1 , ATP-binding cassette sub-family C ( CFTR/MRP) member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1

GENE ID SPEZIES
4363 Homo sapiens
17250 Mus musculus
403453 Canis lupus familiaris
281588 Bos taurus
395416 Gallus gallus
733619 Sus scrofa
100734674 Cavia porcellus
24565 Rattus norvegicus
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