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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antikörper (31) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest both PXR (zeige NR1I2 Proteine) and CAR are expressed in testis/Sertoli cells; exposure of Sertoli cells (in vitro model of blood-testis barrier) to PXR (zeige NR1I2 Proteine) or CAR ligands (including antiretroviral drugs) up-regulates expression of Pgp/ABCB1 (zeige ABCB4 Proteine), BCRP, and MRP4 (zeige ABCC4 Proteine). (PXR (zeige NR1I2 Proteine) = pregnane X receptor (zeige NR1I2 Proteine); CAR = constitutive androstane receptor (zeige NR1I3 Proteine); Pgp/ABCB1 (zeige ABCB4 Proteine) = P-glycoprotein ABCB1 (zeige ABCB1 Proteine); BCRP = breast cancer resistance protein; MRP4 (zeige ABCC4 Proteine) =multidrug resistance protein 4)
in patients with chronic myeloid leukemia (zeige BCL11A Proteine), the study of ABCB1 (zeige ABCB1 Proteine) polymorphism showed that the optimal response rate to imatinib did not differ significantly between C1236T, G2677T/A or C3435T genotypes; however, the 1236C-2677A-3435C haplotype was observed only in imatinib non-responders, suggesting that CAC (zeige CA2 Proteine) haplotype was linked to higher risk of imatinib resistance
our findings demonstrated that MDR1 expression is regulated by CDX2 (zeige CDX2 Proteine) and is related to drug resistance in ovarian mucinous adenocarcinoma.
Compared with the sensitive group, both mdr1 mRNA and P-gp (zeige ABCB4 Proteine) expressions increased in the resistant group
an SNP in ABCB1 (zeige ABCB1 Proteine) (rs2032582: 2677G > T/A) was significantly associated with atorvastatin-induced liver injury (AILI) indicating that the G allele might be a risk factor for AILI in Japanese population
impact of CYP4F2, ABCB1 (zeige ABCB1 Proteine), and GGCX (zeige GGCX Proteine) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation
Collectively, the data establish a hitherto unknown liaison among MDR1, BMI1 (zeige BMI1 Proteine) and TIP60 (zeige KAT5 Proteine) and provide mechanistic insights into cisplatin-induced MDR1 expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
High ABCB1 (zeige ABCB1 Proteine) expression is associated with hepatocellular carcinoma.
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
ATPase measurements imply that DCV and Ho are similarly handled by ABCB1, whereas ABCG2 seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 multidrug transporter
Loss of ABCB1 (zeige ABCB1 Proteine) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (zeige ABCB4 Proteine) activity and reverse the up-regulated P-gp (zeige ABCB4 Proteine) and MDR1 (zeige ABCB4 Proteine) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (zeige ABCB4 Proteine) gene expression and activity in an enantiomer-specific way.
Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
Data show that human transgenic mutant huntingtin (zeige HTT Proteine) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (zeige ABCB4 Proteine)) which suggests that MDR1 (zeige ABCB4 Proteine) might be a potential therapeutic target for Huntington's disease.
In vitro and in vivo downregulation of the ATP binding cassette transporter (zeige ABCC3 Proteine) B1 by the HMG-CoA reductase (zeige HMGCR Proteine) inhibitor simvastatin
Efficient chemoprotection of CDD (zeige CDA Proteine) and MDR1 (zeige ABCB4 Proteine) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (zeige FOXC1 Proteine)-C and anthracycline application
These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (zeige ABCB1 Proteine)-1Delta mutant mice following exposure to various P-gp (zeige ABCB4 Proteine) substrates.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1