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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ABCB1B Primary Antibody für FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
Show all 2 Pubmed References
Compared with the sensitive group, both mdr1 (zeige TBC1D9 Antikörper) mRNA and P-gp (zeige ABCB4 Antikörper) expressions increased in the resistant group
an SNP in ABCB1 (zeige ABCB1 Antikörper) (rs2032582: 2677G > T/A) was significantly associated with atorvastatin-induced liver injury (AILI) indicating that the G allele might be a risk factor for AILI in Japanese population
impact of CYP4F2 (zeige CYP4F2 Antikörper), ABCB1 (zeige ABCB1 Antikörper), and GGCX (zeige GGCX Antikörper) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation
Collectively, the data establish a hitherto unknown liaison among MDR1 (zeige TBC1D9 Antikörper), BMI1 (zeige BMI1 Antikörper) and TIP60 (zeige KAT5 Antikörper) and provide mechanistic insights into cisplatin-induced MDR1 (zeige TBC1D9 Antikörper) expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
High ABCB1 (zeige ABCB1 Antikörper) expression is associated with hepatocellular carcinoma.
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 (zeige TBC1D9 Antikörper) gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
ATPase (zeige DNAH8 Antikörper) measurements imply that DCV and Ho are similarly handled by ABCB1 (zeige ABCB1 Antikörper), whereas ABCG2 (zeige ABCG2 Antikörper) seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 (zeige ABCG2 Antikörper) multidrug transporter
These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 (zeige ABCC1 Antikörper) in recipient cells is governed by the transfer of both miR (zeige MLXIP Antikörper)-326 and ABCB1 (zeige ABCB1 Antikörper) from donor cells
he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 (zeige TBC1D9 Antikörper) treansporter in non-small-cell lung carcinoma (NSCLC) cells.
An additional action of osimertinib that directly inhibits the function of ABCB1 (zeige ABCB1 Antikörper).
Loss of ABCB1 (zeige ABCB1 Antikörper) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (zeige ABCB4 Antikörper) ATPase (zeige DNAH8 Antikörper) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (zeige ABCB4 Antikörper) activity and reverse the up-regulated P-gp (zeige ABCB4 Antikörper) and MDR1 (zeige ABCB4 Antikörper) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (zeige ABCB4 Antikörper) gene expression and activity in an enantiomer-specific way.
Pgp (zeige ABCB4 Antikörper)-coupled ATPase (zeige DNAH8 Antikörper) activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
Data show that human transgenic mutant huntingtin (zeige HTT Antikörper) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (zeige ABCB4 Antikörper)) which suggests that MDR1 (zeige ABCB4 Antikörper) might be a potential therapeutic target for Huntington's disease.
In vitro and in vivo downregulation of the ATP binding cassette transporter (zeige ABCC3 Antikörper) B1 by the HMG-CoA reductase (zeige HMGCR Antikörper) inhibitor simvastatin
Efficient chemoprotection of CDD (zeige CDA Antikörper) and MDR1 (zeige ABCB4 Antikörper) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (zeige FOXC1 Antikörper)-C and anthracycline application
These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (zeige ABCB1 Antikörper)-1Delta mutant mice following exposure to various P-gp (zeige ABCB4 Antikörper) substrates.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1