ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine (ABCB1)

The membrane-associated protein encoded by ABCB1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Antikörper (280) und ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Kits (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ABCB1 5243 P08183
Ratte ABCB1 ABCB1 170913  
Maus ABCB1 ABCB1 18669 P06795
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine auf antikoerper-online.de

Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 70 bis 75 Tage
$12,906.52
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Insect cells (Sf9) Human DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$460.85
Details
Hefe REACT_Entamoeba histolytica His tag   500 μg Anmelden zum Anzeigen 60 bis 71 Tage
$962.50
Details

ABCB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Am meisten referenzierte ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Proteine

  1. Human ABCB1 Protein expressed in Wheat germ - ABIN1305435 : Kamiie, Ohtsuki, Iwase, Ohmine, Katsukura, Yanai, Sekine, Uchida, Ito, Terasaki: Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. in Pharmaceutical research 2008 (PubMed)

Weitere Proteine zu ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartnern

Cow (Bovine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. P-gp (zeige ABCB4 Proteine), Bcrp and Mrp1 (zeige ABCC1 Proteine) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  2. This study has, for the first time, confirmed the expression of ABCB1 in epithelial cells of the bovine rumen.

  3. Bovine blastocysts stimulated by the combined treatment with forskolin, rifampicin, and interferon-alpha to express high levels of ATP-binding cassette subfamily B member 1 displayed better freezing resistance

  4. ABCB1 is expressed in bovine oocytes and embryos.

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. Compared with the sensitive group, both mdr1 mRNA and P-gp (zeige ABCB4 Proteine) expressions increased in the resistant group

  2. an SNP in ABCB1 (rs2032582: 2677G > T/A) was significantly associated with atorvastatin-induced liver injury (AILI) indicating that the G allele might be a risk factor for AILI in Japanese population

  3. impact of CYP4F2, ABCB1, and GGCX (zeige GGCX Proteine) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation

  4. Collectively, the data establish a hitherto unknown liaison among MDR1, BMI1 (zeige BMI1 Proteine) and TIP60 (zeige KAT5 Proteine) and provide mechanistic insights into cisplatin-induced MDR1 expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.

  5. High ABCB1 expression is associated with hepatocellular carcinoma.

  6. Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.

  7. ATPase measurements imply that DCV and Ho are similarly handled by ABCB1, whereas ABCG2 seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 multidrug transporter

  8. These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 (zeige ABCC1 Proteine) in recipient cells is governed by the transfer of both miR (zeige MLXIP Proteine)-326 and ABCB1 from donor cells

  9. he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 treansporter in non-small-cell lung carcinoma (NSCLC) cells.

  10. An additional action of osimertinib that directly inhibits the function of ABCB1.

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Interaktionspartner

  1. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

  2. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  3. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  4. Chrysosplenetin inhibited P-gp (zeige ABCB4 Proteine) activity and reverse the up-regulated P-gp (zeige ABCB4 Proteine) and MDR1 (zeige ABCB4 Proteine) levels induced by artemisinin.

  5. Tamsulosin and tolterodine with P-gp (zeige ABCB4 Proteine) gene expression and activity in an enantiomer-specific way.

  6. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  7. Data show that human transgenic mutant huntingtin (zeige HTT Proteine) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (zeige ABCB4 Proteine)) which suggests that MDR1 (zeige ABCB4 Proteine) might be a potential therapeutic target for Huntington's disease.

  8. In vitro and in vivo downregulation of the ATP binding cassette transporter (zeige ABCC3 Proteine) B1 by the HMG-CoA reductase (zeige HMGCR Proteine) inhibitor simvastatin

  9. Efficient chemoprotection of CDD (zeige CDA Proteine) and MDR1 (zeige ABCB4 Proteine) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (zeige FOXC1 Proteine)-C and anthracycline application

  10. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp (zeige ABCB4 Proteine) substrates.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1) Protein Überblick

Protein Überblick

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Genbezeichner und Symbole assoziert mit ABCB1

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP binding cassette subfamily B member 1 L homeolog (abcb1.L)
  • ATP binding cassette subfamily B member 1A (Abcb1a)
  • ATP binding cassette subfamily B member 1 (Abcb1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • malic enzyme complex, mitochondrial (Mod2)
  • ABC20 Protein
  • ABCB1 Protein
  • Cd243 Protein
  • CLCS Protein
  • GP170 Protein
  • Mdr Protein
  • Mdr-1 Protein
  • Mdr1 Protein
  • Mdr1a Protein
  • Mdr1b Protein
  • Mod-2 Protein
  • Mod-2r Protein
  • Mod-2s Protein
  • Mod2-r Protein
  • Mod2-s Protein
  • p-gp Protein
  • PGP1 Protein
  • Pgy-1 Protein
  • Pgy1 Protein
  • xemdr Protein

Bezeichner auf Proteinebene für ABCB1

bovine P-glycoprotein , multidrug resistance protein 1 , multidrug resistance protein , ATP-binding cassette sub-family B member 1 , P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , ATP-binding cassette, subfamily B, member 1 , P-glycoprotein , multidrug resistance p-glycoprotein , ATP-binding cassette, sub-family B (MDR/TAP), member 1 , ATP-binding cassette, subfamily B (MDR/TAP), member 1A , multiple drug resistant 1a , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1 , malic enzyme complex, mitochondrial , malic enzyme, mitochondrial regulatory , malic enzyme, mitochondrial structural

GENE ID SPEZIES
281585 Bos taurus
397812 Xenopus laevis
463516 Pan troglodytes
5243 Homo sapiens
403879 Canis lupus familiaris
170913 Rattus norvegicus
100682536 Cricetulus griseus
18669 Mus musculus
24646 Rattus norvegicus
110357 Mus musculus
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