anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Antikörper

The membrane-associated protein encoded by ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ABCA4 Proteine (10) und ABCA4 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ABCA4 24 P78363
ABCA4 11304 O35600
ABCA4 310836  
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Top anti-ABCA4 Antikörper auf antikoerper-online.de

Showing 10 out of 58 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Maus Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Maus Kaninchen Unkonjugiert WB Anti-ABCA4 antibody, Western blotting All lanes: Anti ABCA4  at 0.5ug/ml WB: Mouse Brain Tissue Lysate at 50ug Predicted bind size: 256KD Observed bind size: 256KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$200.00
Details
Human Kaninchen Unkonjugiert WB Anti-ABCA4 antibody, Western blotting WB: U87 Cell Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$200.00
Details
Rind (Kuh) Maus Unkonjugiert IHC (fro), IHC, WB Immunohistochemistry: ABCA4 Antibody (3F4) [NBP1-30032] - staining of adult mouse retina showing specific immunolabeling of the ABCA4 protein. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$447.56
Details
Hund Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$317.63
Details
Rind (Kuh) Maus Unkonjugiert IHC (fro), WB   0.1 mL Anmelden zum Anzeigen 10 bis 12 Tage
$375.38
Details
Hund Kaninchen Unkonjugiert WB Western blot analysis of ABCA4 expression in HEK293T (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$317.63
Details
Human Kaninchen Unkonjugiert IHC (p), ELISA 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$375.83
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using ABCA4 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details

ABCA4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-ABCA4 Antikörper

  1. Cow (Bovine) Monoclonal ABCA4 Primary Antibody für IHC (fro), IHC - ABIN447448 : Wiszniewski, Zaremba, Yatsenko, Jamrich, Wensel, Lewis, Lupski: ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies. in Human molecular genetics 2005 (PubMed)
    Show all 2 Pubmed References

  2. Dog (Canine) Polyclonal ABCA4 Primary Antibody für ELISA - ABIN408723 : Singh, Jalali, Hejtmancik, Kannabiran: Homozygous null mutations in the ABCA4 gene in two families with autosomal recessive retinal dystrophy. in American journal of ophthalmology 2006 (PubMed)

  3. Human Polyclonal ABCA4 Primary Antibody für ELISA - ABIN449914 : Allocca, Doria, Petrillo, Colella, Garcia-Hoyos, Gibbs, Kim, Maguire, Rex, Di Vicino, Cutillo, Sparrow, Williams, Bennett, Auricchio: Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. in The Journal of clinical investigation 2008 (PubMed)

Weitere Antikörper gegen ABCA4 Interaktionspartner

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Interaktionspartner

  1. Segregation analysis is important in order to confirm the molecular diagnosis of patients with Stargardt disease, given the frequency of complex alleles in the ABCA4 gene. The various pathogenic variation combinations observed in this study were associated with different phenotypes.

  2. This study describes the functional effect and the molecular mechanism of the pathogenic ABCA4 variant c.5461-10T>C. The variant is functionally important as it leads to splicing defects and a reduced level of ABCA4 protein.

  3. study to determine the effect of 15 individual ABCA4 mutations on retinal disease severity; in the hemizygous state, 2/15 ABCA4 alleles retain preserved peripheral retinal function; 7/15 are associated with either preserved or only mildly abnormal retinal function, worse in older patients; 6/15 behave like null mutations

  4. The ABCA4 variant c.5461-10T-->C is located on a founder haplotype lacking other disease-causing rare sequence variants. In vitro studies revealed that it leads to mRNA exon skipping and ABCA4 protein truncation.

  5. Genetic risk score estimates suggest that defined common ABCA4 variants influence disease risk in carriers of a single pathogenic ABCA4 allele.

  6. A combination of p.[(L541P; A1038V)] and/or a truncating ABCA4 mutation always resulted in an early disease onset. Identification of ABCA4 retinopathies provides a specific molecular diagnosis and justifies a prompt introduction of simple precautions that may slow disease progression.

  7. Nullizygosity for ABCA4 is associated with early onset cone-rod dysfunction with rapid progression shown by enlargement of central atrophy on FAF (zeige FANCF Antikörper), decline of ERG (zeige ERG Antikörper) amplitudes with age, and a high risk of reaching legal blindness by the fourth decade.

  8. Results identified nonsynonymous variants in MYH9 (zeige MYH9 Antikörper) and ABCA4 to be the most frequent risk loci in nonsyndromic orofacial clefts in the Taiwanese population.

  9. 1268A>G missense variant of the ABCA4 gene has often been reported as causative of disease, and in other cases protective of disease, in our family case, the variant appears to reduce or delay the risk of onset of Stargardt disease.

  10. Of the 225 genetic tests performed, 150 were for recessive IRD (zeige SCRIB Antikörper), and 75 were for dominant IRD (zeige SCRIB Antikörper). A positive molecular diagnosis was made in 70 (59%) of probands with recessive IRD (zeige SCRIB Antikörper) and 19 (26%) probands with dominant IRD (zeige SCRIB Antikörper). Thirty-two novel variants were identified; among these, 17 sequence changes in four genes were predicted to be possibly or probably damaging including: ABCA4 (14), BEST1 (zeige BEST1 Antikörper) (2), PRPH2 (zeige PRPH2 Antikörper) (1), and TIMP3 (zeige TIMP3 Antikörper)

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Interaktionspartner

  1. a comprehensive analysis using RNA-seq identified important roles of the acute stress response in the degenerating retina of Abca4-/-Rdh8 (zeige HSD17B6 Antikörper)-/- mice that are predisposed to retinal degeneration under light stress.

  2. Data indicate that knocking out the ATP-binding cassette transporter Abca4 gene correlated with an increase in all orange pigments.

  3. The viral oncoprotein HBx of Hepatitis B virus promotes the growth of hepatocellular carcinoma through cooperating with the cellular oncoprotein RMP.

  4. Despite pronounced lipofuscin accumulation in the retinal pigment epithelium of Abca4(-/-) mice, ERG (zeige ERG Antikörper) and histology showed a slow age-related thinning of the photoreceptor layer similar to wild type controls up to 12 months.

  5. Abca4-deficient mice accumulate more of the toxic bisretinoid A2E than their ABCA4-competent counterparts which contribute to primary cone toxicity and may be associated with macular vision loss

  6. Mutations known to cause Stargardt disease decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activity of ABCA4

  7. The physiological role of Abca4 may include the translocation of 11-cis (zeige CISH Antikörper)-retinal complexes across the disk membrane

  8. Upregulation of Abca4 in the liver is a tissue-specific compensatory consequence of the 'knock-out' of Abcc6 (zeige ABCC6 Antikörper) in mice.

  9. Abcr (-/-) mice exhibit progressive photoreceptor cell loss that is detectable at 8 months of age and that has worsened by 11 and 13 months of age.

  10. In 2-month-old Abca4-/- mice, A2E was found in the center of the retinal pigment epithelial tissue; with age, A2E increased across the tissue

Xenopus laevis ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Interaktionspartner

  1. Evolutionary alterations may increase the retinoid metabolite recycling capacity of ABCA4 and may improve dark adaptation.

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 4 (ABCA4) Interaktionspartner

  1. ABCA4 can transport N-11-cis (zeige CISH Antikörper)-retinylidene-phosphatidylethanolamine (PE), the Schiff-base conjugate of 11-cis (zeige CISH Antikörper)-retinal and PE, from the lumen to the cytoplasmic leaflet of disk membranes.

  2. An 18 A-resolution structure of ABCA4 isolated from bovine rod outer segments was determined using electron microscopy and single-particle reconstruction

  3. partial dephosphorylation of native bovine ABCA4 led to reduction of both basal and stimulated ATPase (zeige DNAH8 Antikörper) activity. Thus, we present the first evidence that phosphorylation of ABCA4 can regulate its function

  4. results indicate that ATP binding cassette protein (zeige ABCB5 Antikörper) ABCA4 preferentially binds N-retinylidene-phosphatidylethanolamine with high affinity

ABCA4 Antigen-Profil

Protein Überblick

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Genbezeichner und Symbole assoziert mit ABCA4

  • ATP binding cassette subfamily A member 4 (ABCA4) Antikörper
  • ATP binding cassette subfamily A member 4 (abca4) Antikörper
  • ATP-binding cassette, sub-family A (ABC1), member 4 (Abca4) Antikörper
  • ATP binding cassette subfamily A member 4 L homeolog (abca4.L) Antikörper
  • ATP binding cassette subfamily A member 4 (Abca4) Antikörper
  • Abc10 Antikörper
  • Abcr Antikörper
  • ARMD2 Antikörper
  • AW050280 Antikörper
  • CORD3 Antikörper
  • D430003I15Rik Antikörper
  • FFM Antikörper
  • RmP Antikörper
  • RP19 Antikörper
  • STGD Antikörper
  • STGD1 Antikörper

Bezeichner auf Proteinebene für ABCA4

ATP-binding cassette sub-family A member 4 , retinal-specific ATP transporter ABCA4 , ATP-binding cassette, sub-family A member 4 , ATP-binding cassette, sub-family A (ABC1), member 4 , retinal-specific ATP-binding cassette transporter-like , ATP binding cassette transporter , ATP-binding cassette transporter, retinal-specific , ATP-binding transporter, retina-specific , RIM ABC transporter , RIM protein , photoreceptor rim protein , retina-specific ABC transporter , retinal-specific ATP-binding cassette transporter , stargardt disease protein , ATP-binding cassette 10 , Rim protein , ATP-binding cassette, sub-family A, member 4 , retinal ABCA4 transporter

GENE ID SPEZIES
424490 Gallus gallus
496442 Xenopus (Silurana) tropicalis
745972 Pan troglodytes
100393904 Callithrix jacchus
100440877 Pongo abelii
100479076 Ailuropoda melanoleuca
100605850 Nomascus leucogenys
24 Homo sapiens
444852 Canis lupus familiaris
11304 Mus musculus
497268 Xenopus laevis
281584 Bos taurus
310836 Rattus norvegicus
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