APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 Proteine (APEX2)

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Zusätzlich bieten wir Ihnen APEX2 Antikörper (60) und APEX2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
APEX2 27301 Q9UBZ4
Ratte APEX2 APEX2 289662  
APEX2 77622 Q68G58
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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APEX2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartnern

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. APE2 associates with Chk1 (zeige CHEK1 Proteine); a serine residue (S86) in the Chk1 (zeige CHEK1 Proteine)-binding motif of APE2 is essential for Chk1 (zeige CHEK1 Proteine) phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 (zeige CHEK1 Proteine) signaling.

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. Determinants in nuclease (zeige DCLRE1C Proteine) specificity of Ape1 (zeige APEX1 Proteine) and Ape2, human homologues of Escherichia coli exonuclease (zeige EXO1 Proteine) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (zeige PCNA Proteine)-dependent repair synthesis.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE (zeige RPLP0 Proteine)) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (zeige AICDA Proteine) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (zeige APEX1 Proteine) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (zeige AKAP17A Proteine) transition, due to a p53 (zeige TP53 Proteine)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (zeige APEX1 Proteine).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (zeige APEX1 Proteine) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Protein Überblick

Protein Überblick

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit APEX2

  • apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2)
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2)
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L)
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2)
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2)
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 (Apex2l1)
  • apurinic/apyrimidinic endonuclease 2 (Apex2)
  • APE2 Protein
  • APEXL2 Protein
  • C430040P13Rik Protein
  • XTH2 Protein
  • zgc:55889 Protein

Bezeichner auf Proteinebene für APEX2

DNA-(apurinic or apyrimidinic site) lyase 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like , AP endonuclease 2 , AP endonuclease XTH2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2

GENE ID SPEZIES
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
27301 Homo sapiens
491499 Canis lupus familiaris
511790 Bos taurus
289662 Rattus norvegicus
77622 Mus musculus
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