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anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Antikörper

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. Zusätzlich bieten wir Ihnen APEX2 Proteine (3) und APEX2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
APEX2 27301 Q9UBZ4
APEX2 289662  
APEX2 77622 Q68G58
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Top anti-APEX2 Antikörper auf antikoerper-online.de

Showing 10 out of 59 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB Western blot analysis of APEX2 Antibody (Center) (ABIN652924) in MCF-7 cell line lysates (35 µg/lane). APEX2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with APEX2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert WB Western Blot: APEX2 Antibody [ABIN42810615] - Western blot analysis of APEXL2 in HeLa cell lysates using ABIN42810615 at a dilution of 1:500. 0.2 mL Anmelden zum Anzeigen 2 bis 4 Tage
242,00 €
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Human Kaninchen Unkonjugiert IHC (p), WB 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
517,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- APEX2 antibody, Western blotting All lanes: Anti APEX2  at 0.5ug/ml WB: SMMC Whole Cell Lysate at 40ug Predicted bind size: 57KD Observed bind size: 57KD Anti- APEX2 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
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Rind (Kuh) Kaninchen Unkonjugiert IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details
Ratte Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 8 bis 11 Tage
340,48 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2 Polyclonal Antibody, Unconjugated (ABIN718481) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
Details
Human Kaninchen Unkonjugiert WB APEXL2 pAb tested by Western blot. APEXL2 detection by Western blot. The analysis of APEXL2 was performed using HeLa whole-cell extract and APEXL2 pAb at a 1:500 dilution. 200 μL Anmelden zum Anzeigen 1 bis 3 Tage
497,22 €
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Rind (Kuh) Kaninchen Unkonjugiert IHC (p), WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
548,26 €
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Human Kaninchen APC IHC, ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.150,64 €
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APEX2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-APEX2 Antikörper

  1. Human Polyclonal APEX2 Primary Antibody für FACS, IF - ABIN652924 : Hadi, Ginalski, Nguyen, Wilson: Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. in Journal of molecular biology 2002 (PubMed)

  2. Human Polyclonal APEX2 Primary Antibody für WB - ABIN4281061 : Karkhanis, Wang, Tae, Hu, Imbalzano, Sif: Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1. in The Journal of biological chemistry 2012 (PubMed)

Weitere Antikörper gegen APEX2 Interaktionspartner

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. APE2 associates with Chk1 (zeige CHEK1 Antikörper); a serine residue (S86) in the Chk1 (zeige CHEK1 Antikörper)-binding motif of APE2 is essential for Chk1 (zeige CHEK1 Antikörper) phosphorylation, indicating a Claspin (zeige CLSPN Antikörper)-like but distinct role for APE2 in ATR (zeige ATR Antikörper)-Chk1 (zeige CHEK1 Antikörper) signaling.

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. Determinants in nuclease (zeige DCLRE1C Antikörper) specificity of Ape1 (zeige APEX1 Antikörper) and Ape2, human homologues of Escherichia coli exonuclease (zeige EXO1 Antikörper) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (zeige PCNA Antikörper)-dependent repair synthesis.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Interaktionspartner

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE (zeige RPLP0 Antikörper)) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (zeige AICDA Antikörper) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (zeige APEX1 Antikörper) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (zeige AKAP17A Antikörper) transition, due to a p53 (zeige TP53 Antikörper)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (zeige APEX1 Antikörper).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (zeige APEX1 Antikörper) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 Antigen-Profil

Protein Überblick

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit APEX2

  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) Antikörper
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) Antikörper
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 (Apex2l1) Antikörper
  • apurinic/apyrimidinic endonuclease 2 (Apex2) Antikörper
  • APE2 Antikörper
  • APEXL2 Antikörper
  • C430040P13Rik Antikörper
  • XTH2 Antikörper
  • zgc:55889 Antikörper

Bezeichner auf Proteinebene für APEX2

DNA-(apurinic or apyrimidinic site) lyase 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like , AP endonuclease 2 , AP endonuclease XTH2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2

GENE ID SPEZIES
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
27301 Homo sapiens
491499 Canis lupus familiaris
511790 Bos taurus
289662 Rattus norvegicus
77622 Mus musculus
Ausgewählte Anbieter für anti-APEX2 (APEX2) Antikörper
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