anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Antikörper

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Zusätzlich bieten wir Ihnen ADAMTS5 Kits (38) und ADAMTS5 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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Showing 10 out of 121 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of anti-ADAMTS5 Antibody (Center) in mouse muscle tissue lysates (35ug/lane). ADAMTS5(arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Maus Kaninchen Unkonjugiert WB Western blot analysis of anti-ADAMTS5 Antibody (Center) (ABIN391652) in mouse muscle tissue lysates (35 µg/lane). ADAMTS5(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-ADAMTS5 antibody, IHC(P) IHC(P): Rat Brain Tissue 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit Anti Aggrecanase-2/ADAMTS5 Polyclonal Antibody, Unconjugated (ABIN701005) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Aggrecanase-2/ADAMTS5 Polyclonal Antibody, Unconjugated (ABIN701005) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
Details
Human Kaninchen Unkonjugiert WB ADAMTS5 Antibody (N-term) (ABIN657768) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the ADAMTS5 antibody detected the ADAMTS5 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using ADAMTS5, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: JC 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Details
Human Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 8 bis 11 Tage
340,48 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP2-15286] - Paraffin-embedded Hepatoma, using antibody at 1:500 dilution. Western Blot: ADAMTS5 Antibody [NBP2-15286] - Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 7. 5% SDS PAGE, antibody diluted at 1:3000. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of ADAMTS5 expression in Hela (A), PC12 (B), mouse testis (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
Details
Fledermaus Kaninchen Unkonjugiert IHC (p) Anti-ADAMTS5 antibody  ABIN1048295 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
Details

ADAMTS5 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-ADAMTS5 Antikörper

  1. Human Polyclonal ADAMTS5 Primary Antibody für EIA, WB - ABIN359611 : Abbaszade, Liu, Yang, Rosenfeld, Ross, Link, Ellis, Tortorella, Pratta, Hollis, Wynn, Duke, George, Hillman, Murphy, Wiswall, Copeland, Decicco, Bruckner, Nagase, Itoh, Newton, Magolda, Trzaskos, Burn: Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. in The Journal of biological chemistry 1999 (PubMed)
    Zeige alle 2 Referenzen für 359611

  2. Mouse (Murine) Polyclonal ADAMTS5 Primary Antibody für WB - ABIN391652 : Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000 (PubMed)
    Zeige alle 2 Referenzen für 391652

Weitere Antikörper gegen ADAMTS5 Interaktionspartner

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaktionspartner

  1. research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality

  2. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (zeige ACAN Antikörper) and Vcan (zeige Vcan Antikörper) by an ADAMTS (zeige ADAMTS1 Antikörper) other than TS5.

  3. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (zeige ADAMTS4 Antikörper) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  4. aggrecan (zeige ACAN Antikörper) and brevican (zeige BCAN Antikörper) proteolysis is compensated in Adamts4 (zeige ADAMTS4 Antikörper)-/- or Adamts5-/- mice by ADAMTS (zeige ADAMTS1 Antikörper) proteoglycanase (zeige MMP3 Antikörper) family members but a threshold of versican (zeige Vcan Antikörper) proteolysis is sensitive to the loss of a single ADAMTS (zeige ADAMTS1 Antikörper) proteoglycanase (zeige MMP3 Antikörper) during spinal cord injury

  5. The present study reveals ADAMT-5 expression by mast cells(MCs (zeige SMCP Antikörper)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  6. Western blot analyses indicated that aggrecanase (zeige ADAMTS4 Antikörper)-generated proteoglycan (zeige Vcan Antikörper) fragments are produced after SCI.

  7. RelA/p65 (zeige NFkBP65 Antikörper) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  8. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

  9. this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.

  10. The serine protease (zeige F2 Antikörper) tissue plasminogen activator (tPA (zeige PLAT Antikörper)) and two matrix metalloproteinases, ADAMTS-4 (zeige ADAMTS4 Antikörper) and ADAMTS-5, were identified as Reelin (zeige RELN Antikörper) cleaving enzymes.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaktionspartner

  1. Results provide direct evidence indicating that Fibulin-2 (zeige FBLN2 Antikörper) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (zeige FBLN2 Antikörper) and the ADAMTSs metalloproteases.

  2. Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13 (zeige MMP13 Antikörper), and decreased COL2A1 (zeige COL2A1 Antikörper) expression.

  3. Single Nucleotide Variants of Candidate Genes in Aggrecan (zeige ACAN Antikörper) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  4. RREB1 (zeige RREB1 Antikörper) cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM (zeige MMRN1 Antikörper)) of the intervertebral disc.

  5. Matrilin 2 (zeige MATN2 Antikörper) accumulation associated with relative ADAMTS5 deficiency may contribute to the mechanism underlying calcific aortic valve disease progression.

  6. In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13 (zeige MMP13 Antikörper), ADAMTS-5, and HDAC-4 (zeige HDAC4 Antikörper), and modulates the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway activation.

  7. we investigated whether important polymorphisms in the ADAMTS4 (zeige ADAMTS4 Antikörper) and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 (zeige ADAMTS4 Antikörper) and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (zeige ADAMTS4 Antikörper) (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.

  8. Increased ADAMTS5 levels were observed in placental insufficiency cases.

  9. ADAMTS5 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS5 protein expression.

  10. Overexpression of ADAMTS5 is associated with migration and invasion of non-small cell lung cancer.

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaktionspartner

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (zeige ADAMTS4 Antikörper)) explains the minor contribution of the MMP enzymes to aggrecan (zeige ACAN Antikörper) catabolism in vivo.

  2. ADAMTS4 (zeige ADAMTS4 Antikörper) and ADAMTS5 are inhibited by alpha2-macroglobulin (zeige A2M Antikörper)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (zeige ADAMTS4 Antikörper) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 Antigen-Profil

Protein Überblick

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Genbezeichner und Symbole assoziert mit ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (adamts5) Antikörper
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) Antikörper
  • 9530092O11Rik Antikörper
  • ADAM-TS5 Antikörper
  • ADAM-TS 5 Antikörper
  • ADAM-TS 11 Antikörper
  • ADAMTS-5 Antikörper
  • ADAMTS-11 Antikörper
  • ADAMTS1 Antikörper
  • ADAMTS11 Antikörper
  • ADMP-2 Antikörper
  • AI481094 Antikörper
  • ASMP-2 Antikörper

Bezeichner auf Proteinebene für ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPEZIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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