anti-7-Dehydrocholesterol Reductase (DHCR7) Antikörper

DHCR7 encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. Zusätzlich bieten wir Ihnen DHCR7 Kits (9) und DHCR7 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DHCR7 13360 O88455
DHCR7 64191 Q9Z2Z8
DHCR7 1717 Q9UBM7
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Showing 10 out of 44 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Maus Kaninchen Unkonjugiert IF, IHC (p), WB DHCR7 Antibody (C-term) (ABIN655399) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Human HL-60 cell lysates probed with Anti-DHCR7 Polyclonal Antibody, Unconjugated  at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody -HRP) at 1:10000 for 90 min at 37˚C. 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
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Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using DHCR7 antibody. 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
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Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy5.5 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy3 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy5 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Cy7 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen HRP IHC (p), WB   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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DHCR7 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen DHCR7 Interaktionspartner

Xenopus laevis 7-Dehydrocholesterol Reductase (DHCR7) Interaktionspartner

  1. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog (zeige SHH Antikörper) are co-expressed during midline development in Xenopus embryos.

  2. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system

Arabidopsis thaliana 7-Dehydrocholesterol Reductase (DHCR7) Interaktionspartner

  1. both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles

Mouse (Murine) 7-Dehydrocholesterol Reductase (DHCR7) Interaktionspartner

  1. Dhcr7 heterozygous mice made fewer ultrasonic vocalizations. Increases of 7-DHC and expression of the serotonin transporter (zeige SLC6A4 Antikörper) were observed in the compound mutant mice.

  2. Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh (zeige SHH Antikörper)), and bone morphogenetic protein-2 (Bmp2 (zeige BMP2 Antikörper)) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol.

  3. significant increases in Col1a1 (zeige COL1A1 Antikörper), serine/threonine-protein kinase 1, Ctnnb1 (zeige CTNNB1 Antikörper), CSRNP1 (zeige CSRNP1 Antikörper), Ddit4 (zeige DDIT4 Antikörper), Cyp2e1 (zeige CYP2E1 Antikörper), and Krit1 (zeige KRIT1 Antikörper) expressions and great decreases inreceptor D2, Neu1 (zeige NEURL Antikörper), and Dhcr7 expressions following long-term exposure to TiO2 NPs (zeige NPS Antikörper)

  4. data indicate an underlying dysfunction of the 5-HT2A receptors in Dhcr7-HET mice that warrants further investigation to establish how this may relate to behavioral disturbances in human patients carrying Dhcr7 mutations

  5. conclude that cytochrome P450 reductase (zeige POR Antikörper) is not involved in 7-dehydrocholesterol reductase activity

  6. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d (zeige SC5DL Antikörper)(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.

  7. Immunohistochemical analyses have revealed a 306% increase in the area of 5-HT (zeige DDC Antikörper) immunoreactivity (5-HT (zeige DDC Antikörper) IR) in the hindbrains of mutant (Dhcr7-/-) mice as compared to age-matched wild type animals.

  8. Of the 12,000 genes analyzed, 91 were upregulated and 98 were downregulated in the Dhcr7-/- hindbrains when compared to wild-type animals.

  9. CNS defects caused by Dhcr7 null likely play a major role in the lethal pathogenesis of Dhcr7-/- mice, with the peripheral organs contributing the morbidity

  10. Data show that in vitro down regulation of NRIF (zeige ZFP110 Antikörper) expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (zeige HMGCR Antikörper) and 7-dehydrocholesterol reductase.

Human 7-Dehydrocholesterol Reductase (DHCR7) Interaktionspartner

  1. phosphorylation modulates DHCR7 activity in cells, and contributes to the overall synthesis of cholesterol, and probably vitamin D

  2. Allelic variations in CYP2R1 (zeige CYP2R1 Antikörper) and GC affect vitamin D levels, but variant alleles on VDR (zeige CYP27B1 Antikörper) and DHCR7 were not correlated with vitamin D deficiency.

  3. Genetic variations in ABCG5 (zeige ABCG5 Antikörper), CYP7A1 (zeige CYP7A1 Antikörper), and DHCR7 may contribute to differing responses of serum cholesterol to dairy intake among healthy adults.

  4. Review: DHCR7 activity should be considered during drug development and prenatal toxicity assessment.

  5. In this study, we demonstrate that the prevalent c.964-1G>C Dhcr7 mutation perturbs SMO cilia localization and SHH (zeige SHH Antikörper) pathway activation as a consequence of reduced cholesterol biosynthesis

  6. these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis.

  7. The aim of this study was to investigate the association of three polymorphisms in the GC gene (rs7041 and rs4588) and CYP2R1 (zeige CYP2R1 Antikörper) gene (rs10741657) on 25-(OH) VD serum concentration among Jordanians.

  8. This study shows that Smith-Lemli-Opitz Syndrome patients who are heterozygous/homozygous for one pathogenic mutation and only one parent carrying that mutation are candidates for DHCR7 gene (partial) deletions.

  9. Polymorphisms in CYP2R1 (zeige CYP2R1 Antikörper)-rs10766197 and DHCR7/NADSYN1 (zeige NADSYN1 Antikörper)-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations

  10. physical and functional interaction between DHCR24 (zeige DHCR24 Antikörper) and DHCR7

DHCR7 Antigen-Profil

Protein Überblick

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS)\; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Genbezeichner und Symbole assoziert mit DHCR7

  • 7-dehydrocholesterol reductase (DHCR7) Antikörper
  • 7-dehydrocholesterol reductase (dhcr7) Antikörper
  • 7-dehydrocholesterol reductase (DWF5) Antikörper
  • 7-dehydrocholesterol reductase (PAAG_04766) Antikörper
  • 7-dehydrocholesterol reductase (PITG_13128) Antikörper
  • 7-dehydrocholesterol reductase (VDBG_05423) Antikörper
  • 7-dehydrocholesterol reductase (MGYG_00712) Antikörper
  • 7-dehydrocholesterol reductase (TERG_00580) Antikörper
  • 7-dehydrocholesterol reductase (Dhcr7) Antikörper
  • 7-Dhcr Antikörper
  • 7-STEROL DELTA7 REDUCTASE Antikörper
  • 7RED Antikörper
  • AA409147 Antikörper
  • DELTA5 Antikörper
  • DKFZp468C1911 Antikörper
  • DWARF 5 Antikörper
  • F11F12.21 Antikörper
  • F11F12_21 Antikörper
  • LE Antikörper
  • LEPIDA Antikörper
  • MGC64361 Antikörper
  • PA Antikörper
  • PARVA Antikörper
  • SLOS Antikörper
  • ST7R Antikörper
  • STEROL DELTA7 REDUCTASE Antikörper
  • xdhcr7 Antikörper

Bezeichner auf Proteinebene für DHCR7

7-DHC reductase , sterol Delta(7)-reductase , 7-dehydrocholesterol reductase , delta-7-dehydrocholesterol reductase , putative sterol reductase SR-2 , sterol delta-7-reductase

GENE ID SPEZIES
100061433 Equus caballus
378446 Danio rerio
380248 Xenopus laevis
394844 Xenopus (Silurana) tropicalis
841465 Arabidopsis thaliana
9096525 Paracoccidioides sp. 'lutzii' Pb01
9472946 Phytophthora infestans T30-4
9531294 Verticillium alfalfae VaMs.102
10031944 Arthroderma gypseum CBS 118893
10374056 Trichophyton rubrum CBS 118892
100172090 Pongo abelii
13360 Mus musculus
64191 Rattus norvegicus
1717 Homo sapiens
422982 Gallus gallus
483675 Canis lupus familiaris
514745 Bos taurus
379273 Xenopus laevis
Ausgewählte Anbieter für anti-DHCR7 (DHCR7) Antikörper
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