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NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. Zusätzlich bieten wir Ihnen 5'-Nucleotidase, Cytosolic II Antikörper (56) und 5'-Nucleotidase, Cytosolic II Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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acute lymphoblastic leukemia-specific mutations affect regulation of cN-II
this study implicates altered neural expression of BORCS7, AS3MT (zeige AS3MT Proteine), and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus
NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.
The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.
Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.
cN-II co-immunoprecipitated both with wild type Ipaf (zeige NLRC4 Proteine) and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf (zeige NLRC4 Proteine) lacking the LRR domain.
Data indicate that type II cytosolic 5'-nucleotidase (zeige NT5E Proteine) (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.
Four novel body mass index-associated loci near the KCNQ1 (zeige KCNQ1 Proteine)(rs2237892), ALDH2 (zeige ALDH2 Proteine)/MYL2 (zeige MYL2 Proteine) (rs671, rs12229654), ITIH4 (zeige ITIH4 Proteine) (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.
These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia
results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia
The results on muscles from the NT5C (zeige NT5C Proteine) knockout mice contradict previous findings where AMP (zeige TMPRSS5 Proteine) levels and AMPK (zeige PRKAA1 Proteine) activity were shown to be modulated by NT5C (zeige NT5C Proteine) enzymes.
mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.
cytosolic 5'-nucleotidase II
, cytosolic purine 5'-nucleotidase
, 5'-nucleotidase, cytosolic II
, 5'-nucleotidase (purine), cytosolic type B
, IMP-specific 5'-NT
, purine 5' nucleotidase
, 5'-nucleotidase cytosolic II
, cytosolic IMP/GMP-specific 5'-nucleotidase
, cytosolic purine 5'-nucleotidase-like