3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) ELISA Kits

The protein encoded by HMGCL belongs to the HMG-CoA lyase family. Zusätzlich bieten wir Ihnen HMGCL Antikörper (109) und HMGCL Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
HMGCL 15356 P38060
HMGCL 3155 P35914
HMGCL 79238 P97519
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) 5.8 pg/mL 23.5-1500 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
874,71 €
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Human
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Maus
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Ratte
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788,70 €
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Weitere ELISA Kits für HMGCL Interaktionspartner

Human 3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL) Interaktionspartner

  1. Data suggest that HMGCS1 (HMG-CoA synthase (zeige HMGCS1 ELISA Kits) 1) signals through ketogenesis/acetoacetate to promote cell proliferation and BRAF (zeige BRAF ELISA Kits)(V600E)-dependent MEK1 (zeige MAP2K1 ELISA Kits) activation in BRAF (zeige BRAF ELISA Kits)(V600E)-positive melanoma and colon cancer cells; HMGCS1 (zeige HMGCS1 ELISA Kits) co-localizes with HMGCL (HMG-CoA lyase) and BRAF (zeige BRAF ELISA Kits)(V600E) in cytosol of melanoma and colon cancer cells. (BRAF (zeige BRAF ELISA Kits) = proto-oncogene (zeige RAB1A ELISA Kits) protein B (zeige LEPREL2 ELISA Kits)-raf (zeige SNRPE ELISA Kits))

  2. The genetic analysis revealed a novel homozygote deletion in exon 3 and 4 in HMGCL gene. HMG-CoA lyase deficiency should be thought in the patients with hypoketotic hypoglycemia, hyperammonemia, elevated liver function tests, noncompaction left ventricle and characteristic white matter changes and in the differential diagnosis of macrocephaly.

  3. this is the first study describing HMGCL deficiency caused by uniparental disomy.

  4. This efficient UPLC-MS/MS assay permits rapid and high sensitive determination of HMGCR (zeige HMGCR ELISA Kits) enzyme activity, tracing potential alterations in cholesterol biosynthesis.

  5. analysis of HMGCLL1 as an extramitochondrial human 3-hydroxy-3-methylglutaryl-CoA lyase and comparison with MHGCL

  6. An alternative transcript of HMGCS2 (zeige HMGCS2 ELISA Kits) carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.

  7. levels of enzyme activity do not strongly correlate with formation of inter-subunit adducts by HMGCL mutants. C170S, C266S, and C323S proteins do not form inter-subunit disulfide adducts but such an adduct is restored in the C170S/C174S double mutant.

  8. Crystal structures of ternary complexes of WT HMGCL with the competitive inhibitor 3-hydroxyglutaryl-CoA and of the catalytically deficient HMGCL R41M mutant with substrate HMG-CoA have been determined to 2.4 and 2.2 A.

  9. We report on a new case of 3-hydroxy-3-methylglutaric aciduria particular by its late onset in a 3-year-old patient. Molecular investigation identified two new sequence modifications in the HMGCL gene: c.494G>A (p.Arg165Gln) and c.820G>A (p.Gly274Arg).

  10. A role is suggested for arginine-41 in deprotonation or enolization of acetyldithio-CoA, implicating this residue in the HMG (zeige SSRP1 ELISA Kits)-CoA cleavage reaction chemistry that leads to acetyl-CoA (zeige LPCAT2 ELISA Kits) product formation.

HMGCL Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit HMGCL

  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573) Antikörper
  • 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl) Antikörper
  • 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) (hmgcl) Antikörper
  • Afu7g01720 Antikörper
  • AO090038000541 Antikörper
  • AW476067 Antikörper
  • HL Antikörper
  • zgc:56248 Antikörper

Bezeichner auf Proteinebene für HMGCL

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase , 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) , 3-hydroxy-3-methylglutarate-CoA lyase , HL , HMG-CoA lyase , hydroxymethylglutaryl-CoA lyase, mitochondrial , 3-hydroxy-3-methylglutaryl-CoA lyase , hydroxymethylglutaricaciduria , mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase , 3-hydroxy-3-methylglutaryl-Coenzyme A lyase

GENE ID SPEZIES
432233 Xenopus laevis
456624 Pan troglodytes
710833 Macaca mulatta
3504221 Aspergillus fumigatus Af293
4589480 Neosartorya fischeri NRRL 181
4704707 Aspergillus clavatus NRRL 1
5997540 Aspergillus oryzae RIB40
7030025 Talaromyces marneffei ATCC 18224
8102925 Talaromyces stipitatus ATCC 10500
9522067 Arthroderma benhamiae CBS 112371
9580122 Trichophyton verrucosum HKI 0517
100174514 Pongo abelii
15356 Mus musculus
3155 Homo sapiens
317658 Bos taurus
79238 Rattus norvegicus
396316 Gallus gallus
394190 Danio rerio
478187 Canis lupus familiaris
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